Notch信号通路调控Treg/Th17细胞机制的研究进展

The research progress on Notch signaling pathway in the regulation of Treg/Th17 cells

Notch家族是多细胞生物发育过程中一类高度保守的、十分重要的跨膜信号蛋白,通过与相邻细胞之间的相互作用,在细胞增殖、分化、凋亡中发挥着关键作用。调节性T细胞(Treg)及辅助性T细胞17(Th17)是目前发现的一类新型CD4+T细胞亚群,在生理状态下,两者可通过分泌多种细胞因子来调节机体免疫的平衡。近年来,越来越多的研究发现Notch信号通路通过调控Treg、Th17细胞参与机体多种疾病的发生。本文就Notch信号通路在血液系统疾病、自身免疫系统疾病等疾病中对Treg/Th17细胞调控机制的研究进展作一简要综述。

Notch family,a kind of important transmembrane signaling proteins,is highly evolutionarily conserved in thedevelopment process of multicellular organisms.Notch signaling pathway can precisely regulate cell development processthrough the interaction between neighboring cells,such as cell proliferation,differentiation and apoptosis.The regulatory T（Treg） cells and T helper 17（Th17） cells are new types of CD4＋T cell subsets.In the physiological state of the organism,theycan secrete relevant various kinds of cytokines,and systematically regulate the balance of immune system.In recent years,more and more studies have found that close relationship between Notch signaling pathway and Treg/Th17 cell balance,which is extensively involved in the various diseases.Therefore,this paper briefly reviewed the regulation mechanism ofNotch signaling pathway on Treg/Th17 cells in diseases such as hematological diseases and autoimmune diseases.