强化剂量阿托伐他汀对冠状动脉介入术后老年患者血脂及血清高敏C反应蛋白水平的影响

Effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein in elderly patients after coronary intervention

目的探讨强化剂量阿托伐他汀对经皮冠状动脉介入(PCI)术后老年患者血脂及血清高敏C反应蛋白(hs-CRP)水平的影响。方法选取2016年7月至2017年7月于海南省人民医院行PCI术的68例冠状动脉粥样硬化性心脏病患者作为研究对象,采用抛硬币法随机分为观察组和对照组,每组34例。对照组患者在常规治疗基础上给予阿托伐他汀10 mg口服治疗,每晚1次;观察组患者在常规治疗基础上给予阿托伐他汀80 mg口服治疗,每晚1次。比较2组患者治疗前后总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及hs-CRP水平。结果治疗前,2组患者总胆固醇、三酰甘油、LDL-C及HDL-C水平比较,差异均无统计学意义(均P>0.05)。2组患者治疗后总胆固醇、三酰甘油、LDL-C水平均明显低于治疗前,HDL-C水平均明显高于治疗前,且观察组患者治疗后总胆固醇、LDL-C水平明显低于对照组,HDL-C水平明显高于对照组,差异均有统计学意义(均P<0.05)。治疗前,观察组与对照组hs-CRP水平比较[(11.2±5.2)mg/L比(10.8±5.1)mg/L],差异无统计学意义(P>0.05),治疗后,观察组与对照组患者的hs-CRP水平[(4.2±1.8)、(7.0±2.9)mg/L]均明显低于本组治疗前,且观察组患者hs-CRP水平明显低于对照组,差异均有统计学意义(均P<0.05)。结论强化剂量阿托伐他汀应用于PCI术后老年患者能有效降低血脂及hs-CRP水平,增强抗炎作用。

Objective To analyze the effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein（hs-CRP） in elderly patients after percutaneous coronary intervention（PCI）. Methods A total of 68 cornary heart disease patients undergoing PCI from July 2016 to July 2017 in Hainan General Hospital were randomly divided into observation group（n = 34） and control group（ n = 34）. The control group took atorvastatin 10 mg every evening; the observation group took atorvastatin 80 mg every evening. Levels of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol （ LDL-C）, high-density lipoprotein cholesterol （ HDL-C ） and hs-CRP were analyzed before and after treatment. Results There were no significant differences of total cholesterol, triacylglycerol, LDL-C and HDL-C levels between groups before treatment （ P 〉 0.05 ）. After treatment, levels of total cholesterol, triacylglycerol and LDL-C were significantly lower and HDL-C was significantly higher than those before treatment in both groups ; levels of total cholesterol and LDL-C in observation group were significantly lower and HDL-C was significantly higher than those in control group（P 〈0.05）. Level of hs-CRP before treatment had no significant difference between observation group and control group [ （11.2 ±5.2）mg/L vs （10.8 ±5.1 ）mg/L] （ P 〉 0.05）. After treatment, level of bs-CRP was significantly lower than that before treatment in both groups ; level of hs-CRP in observation group [ （4. 2 ± 1.8 ） mg/L ] was significantly lower than that in control group [ （7.0 ± 2.9） mg/L] （P 〈 0.05 ）. Conclusion Enhanced dose atorvastatin treating elderly patients after PCI can effectively reduce serum lipid, hs-CRP level and improve the anti-inflammatory action.