乌司他丁治疗急性肺损伤的临床疗效研究

Study on clinical efficacy of ulinastatin in the treatment of acute lung injury

目的探讨乌司他丁治疗急性肺损伤的临床疗效。方法 80例急性肺损伤患者,随机分为对照组和实验组,各40例。对照组患者采用常规治疗,实验组患者在对照组基础上联合乌司他丁治疗,观察比较两组患者治疗效果、呼吸频率(RR)、动脉血氧分压(Pa O_2)、动脉血二氧化碳分压(Pa CO_2)、氧合指数(Pa O_2/Fi O_2)、C反应蛋白(CRP)和乳酸水平差异。结果实验组患者总有效率为90.00%,明显高于对照组的70.00%,差异有统计学意义(P<0.05)。实验组患者RR为(23.46±1.56)次/min,Pa O_2为(92.62±6.38)mm Hg(1 mm Hg=0.133 k Pa),Pa CO_2为(33.99±4.95)mm Hg,Pa O_2/Fi O_2为(281.42±21.83)mm Hg,优于对照组的(27.86±1.74)次/min、(81.05±7.14)mm Hg、(38.85±5.29)mm Hg、(219.74±18.82)mm Hg,差异有统计学意义(P<0.05)。实验组患者CRP为(30.24±3.81)mg/L,乳酸为(1.01±0.15)mmol/L,低于对照组的(41.75±3.53)mg/L、(1.52±0.37)mmol/L,差异有统计学意义(P<0.05)。结论针对急性肺损伤患者应用乌司他丁治疗可明显提高治疗效果,改善血气指标和炎性指标,促进患者康复,值得推广应用。

Objective To discuss the clinical efficacy of ulinastatin in the treatment of acute lung injury. Methods A total of 80 acute lung injury patients were randomly divided into control group and experimental group, with 40 cases in each group. The control group received conventional therapy, and the experimental group received ulinastatin on the basis of the conventional group. Observation and comparison were made on differences in treatment effect, respiratory rate（RR）, partial pressure of oxygen（Pa O2） partial pressure of carbon dioxide（Pa CO2）, oxygenation index（Pa O2/Fi O2）, C reactive protein（CRP） and lactic acid level between the two groups. Results The experimental group had obviously higher total effective rate as 90.00% than 70.00% in the control group, and the difference was statistically significant（P〈0.05）. The experimental group had RR as（23.46± 1.56） times/min, Pa O2 as（92.62±6.38） mm Hg（1 mm Hg=0.133 k Pa）, Pa CO2 as（33.99±4.95） mm Hg and Pa O2/Fi O2 as（281.42±21.83） mm Hg, which were all better than（27.86±1.74） times/min,（81.05±7.14） mm Hg,（38.85±5.29） mm Hg and（219.74±18.82） mm Hg in the control group, and their difference was statistically significant（P〈0.05）. The experimental group had lower CRP as（30.24±3.81） mg/L, lactate as（1.01±0.15） mmol/L than（41.75±3.53）mg/L and（1.52±0.37） mmol/L in the control group, and their difference was statistically significant（P〈0.05）. Conclusion Application of ulinastatin in treating acute lung injury patients can obviously improve treatment effect, improve blood gas index and inflammatory index, and promote rehabilitation of patients. It is worthy of promotion and application.