不同药物溶栓对急性脑梗死的治疗效果对比

Comparison of treatment effects of different drugs thrombolysis on acute cerebral infarction

目的探讨不同药物溶栓在急性脑梗死治疗中的临床效果。方法 80例急性脑梗死患者,根据溶栓治疗药物的不同分为对照组与研究组,每组40例。入院后两组患者均接受相同的对症治疗,在此基础上对照组患者采用尿激酶进行溶栓治疗,研究组患者采用阿替普酶进行溶栓治疗。比较两组患者临床治疗效果、不良反应发生情况、治疗费用及住院时间。结果研究组患者临床治疗总有效率为87.5%,高于对照组的67.5%,差异具有统计学意义(P<0.05)。研究组患者不良反应发生率为5.0%,明显低于对照组的20.0%,差异具有统计学意义(P<0.05)。研究组患者治疗费用高于对照组,住院时间长于对照组,差异具有统计学意义(P<0.05)。结论在急性脑梗死溶栓治疗中,与尿激酶相比,阿替普酶临床疗效更显著,不良反应少,具有疗效好、安全性高的特点,但治疗费用较高、住院时间较长,临床治疗应根据患者情况合理选择。

Objective To discuss the clinical effect of different drugs thrombolysis in the treatment of acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction were divided by different drugs thrombolysis into control group and research group, with 40 cases in each group. After admission, both groups received the same symptomatic treatment. On this basis, the control group was treated with thrombolytic therapy with urokinase, and the research group was treated with thrombolytic therapy with alteplase. Comparison were made on clinical treatment effect, occurrence of adverse reactions, treatment cost and hospitalization time between the two groups. Results The research group had higher total effective rate of clinical treatment as 87.5% than 67.5% in the control group, and the difference was statistically significant（P〈0.05）. The research group had obviously lower incidence of adverse reactions as 5.0% than 20.0% in the control group, and the difference was statistically significant（P〈0.05）. The research group had higher treatment cost than the control group, and longer hospitalization time than the control group. Their difference was statistically significant（P〈0.05）. Conclusion In thrombolytic treatment of acute cerebral infarction, the clinical efficacy of alteplase is more significant than that of urokinase, with less adverse reactions, good efficacy and high safety, but its treatment cost is higher, the time of hospitalization is longer. The clinical treatment should be reasonably selected according to the patient＇s condition.