黏蛋白在结肠息肉中的表达及临床意义

Mucin in colonic polyps and its clinical significance

目的评估黏蛋白(MUC1、MUC2、MUC5AC、MUC6)在不同结肠息肉病理组织中的表达情况,分析黏蛋白的表达对结肠息肉转化的临床价值。方法选择河北省石家庄第一医院2013年1月至2015年1月接受手术治疗结肠息肉的患者120例,根据组织病理诊断分为3组:增生性息肉组患者40例,管状腺瘤组患者40例,绒毛状腺瘤组患者40例。取患者息肉组织,利用免疫组织化学法检测各病理组织中MUC1、MUC2、MUC5AC、MUC6的表达情况。结果在正常结肠黏膜中,MUC1、MUC5AC、MUC6均未表达,而检测到MUC2阳性表达。在管状腺瘤和绒毛状腺瘤中观察到MUC1和MUC6的高表达阳性率,而在增生性息肉中未检测到MUC1和MUC6的阳性表达;MUC2在增生性息肉和腺瘤性息肉中均表现出较高的阳性表达率,且其在增生性息肉和腺瘤性息肉中的阳性表达率呈逐渐下降趋势;MUC5AC在增生性息肉和腺瘤性息肉中均有表达,且增生性息肉中的表达显著低于腺瘤性息肉。结论 MUC1、MUC2、MUC5AC、MUC6在增生性息肉和腺瘤性息肉中阳性表达的差异性与增加的结肠息肉中黏膜或肌层黏膜侵袭风险相关,可作为临床评估结肠息肉发展过程的生物标志物。

Objective To evaluate the expression of mucin（MUC1,MUC2,MUC5 AC and MUC6）in the pathological tissues of different colonic polyps,and to analyze the clinical value of mucin expression in colonic polyp transformation.Methods 120 cases of colonic polyps were selected treated from the First Hospital of Shijiazhuang in Hebeiin hospital from January 2013 to January 2015.According to histopathological diagnosis,there were 3 groups,40 patients with hyperplastic polyps,40 patients with tubular adenoma,40 patients with villous adenoma.The expression of MUC1,MUC2,MUC5 AC and MUC6 in the pathogens were detected by immunohistochemistry.Results In normal colonic mucosa,MUC1,MUC5 AC,MUC6 were not expressed,and MUC2 positive expression was detected.The positive expression rates of high expression of MUC1 and MUC6 were observed in tubular adenoma and villous adenoma,while the positive expression of MUC1 and MUC6 was not detected in proliferative polyps.MUC2 showed a high positive expression rate in hyperplastic polyps and adenomatous polyps,and the positive expression rate in proliferative polyps and adenomatous polypshyperplastic polyps and adenomatous polyps decreased gradually.MUC5 AC was expressed in proliferative polyps and adenomatous polyps,and the expression of MUC5 AC in proliferative polyps was significantly lower than that ofin adenomatous polyps.Conclusion The difference in the positive expression of MUC1,MUC2,MUC5 AC and MUC6 in hyperplastic polyps and adenomatous polyps MUC1,MUC2,MUC5 AC,MUC6 in hyperplastic polyps and adenomatous polyps is associated with the increased risk of mucosal or muscularis mucosa invasion in colonic polyps,which can be used as a biomarker for the clinical diagnosis of the development of colonic polyps.