隐睾患儿血清抗苗勒管激素水平研究

Study on the level of serum Mullerian inhibiting substance in children with cryptorchidism

目的分析不同年龄及不同类型隐睾患儿血清抗苗勒管激素(AMH)水平差异,探讨其在睾丸发育评价中的作用。方法选择60例单纯性隐睾患儿为病例组,52例健康体检儿童为对照组,分别检测两组儿童血清AMH水平,并比较两者之间的差异。结果 (1)病例组AMH水平低于对照组(P<0.05),>6~11岁隐睾患儿与健康儿童间差异无统计学意义(P>0.05)。(2)双侧隐睾组AMH水平低于单侧隐睾组(P<0.05),>6~11岁双侧隐睾与单侧隐睾患儿间差异无统计学意义(P>0.05)。(3)高位型隐睾组AMH水平低于低位型隐睾组(P<0.05),>3~11岁高位型隐睾和低位型隐睾患儿间差异无统计学意义(P>0.05)。(4)AMH水平与年龄呈负相关性,与睾丸发育情况呈正相关性。结论 AMH可作为反映隐睾患儿睾丸发育状况的一项重要指标。

Objective To analyze the difference of serum levels of anti-Mullenan hormone（AMH）in children with different ages and different types of cryptorchidism,and to explore its role in the evaluation of testicular development.Methods 60 children with simple cryptorchidism were selected as case group and 52 healthy children were selected as control group.The levels of serum AMH in two groups of children were measured and the differences were compared.Results（1）The level of AMH in the case group was lower than that in control group（P 0.05）,and there was no statistical significance between two subgroups of 6 to 11 years old children with cryptorchidism and healthy children（P0.05）.（2）The level of AMH in bilateral cryptorchidism group was lower than that in unilateral cryptorchidism group（P0.05）,and there was no significant difference between two subgroups of6 to 11 years old children with bilateral cryptorchidism and unilateral cryptorchidism（P0.05）.（3）The level of AMH in the high level cryptorchidism group was lower than that of the low level cryptorchidism group（P0.05）,and there was no statistical difference between between two subgroups of 3~11 year old children with cryptorchidism and low level cryptorchidism（P0.05）.（4）AMH level was negatively correlated with age,and positively correlated with testicular development.Conclusion AMH can be used as an important indicator of testicular development in children with cryptorchidism.