CK、CK-MB、cTnT及心电图在小儿肺炎治疗前后的变化

Changes of CK,CK-MB,cTnⅠ and electrocardiogram before and after treatment in children with pneumonia

目的探讨血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)及心电图(ECG)在小儿肺炎治疗前后的变化情况。方法选择2014年12月至2016年12月期间收治的肺炎患儿95例为研究组,另选2014年12月至2016年1月期间健康体检儿童48例为对照组。肺炎患儿均于入院后进行治疗。所有研究对象均于入院后及研究组患儿治疗后抽取2mL静脉血,分离血清,测定CK、CK-MB、cTnT水平,同时进行ECG记录。结果治疗前研究组血清CK、CK-MB、cTnT水平高于对照组,差异有统计学意义(P<0.05);研究组ST段抬高或压低、房性早搏、室性早搏、窦性心动过速、窦性心动过缓发生率均高于对照组,且差异有统计学意义(P<0.05);治疗后研究组患儿血清CK、CK-MB、cTnT水平低于治疗前,差异有统计学意义(P<0.05);房性早搏、室性早搏、窦性心动过速、窦性心动过缓发生率均低于治疗前,差异有统计学意义(P<0.05);研究组治疗后ST段抬高或压低发生率低于治疗前,但差异无统计学意义(P>0.05)。结论肺炎患儿血清CK、CK-MB、cTnT及ECG存在明显异常,经治疗后可降低血清CK、CK-MB、cTnT水平,改善ECG异常。

Objective To investigate the changes of serum creatine kinase（CK）,creatine kinase isoenzyme（CK-MB）,cardiac troponin Ⅰ（cTnⅠ）and electrocardiogram（ECG）before and after the treatment of pneumonia in children.Methods From December 2014 to December 2016,95 children with pneumonia were selected as the study group,and 48 healthy subjects who underwent the healthy assessment from December 2014 to January 2016 were selected as the control group.All children with pneumonia were treated after admission.2 mL of venous blood were collected from each research subject after the admission and patients in study group after treatment,serum was seperated,and levels of CK,CK-MB,cTnⅠ were measured and the ECG record was conducted.Results The serum levels of CK,CK-MB and cTnⅠ in the study group were higher than those in the control group（P0.05）;the incidences of ST segment elevation or depression,atrial premature beat,ventricular premature beat,sinus tachycardia and sinus bradycardia in the study group were higher than those in the control group,and the differences were statistically significant（P0.05）;the serum levels of CK,CK-MB and cTnⅠ in the study group were lower than those before treatment,and the difference was statistically significant（P0.05）;the incidences of atrial premature beat,ventricular premature beat,sinus tachycardia and sinus bradycardia in the study group after treatment were lower than those before treatment,and the difference was statistically significant（P0.05）;the incidence of ST segment elevation or depression after treatment in the study group was lower than that before treatment,and there was no significant difference（P0.05）.Conclusion The serum levels of CK,CK-MB,cTnⅠ and ECG were obviously abnormal in children with pneumonia.After treatment,serum CK,CK-MB and cTnⅠ levels can be reduced and ECG abnormalities can be ameliorated.