外周血内CA19-9、CA242、CEA检测对不同病理分期胰腺癌的临床诊断价值

Clinical diagnosis value of CA19-9,CA242 and CEA in peripheral blood of patients with pancreatic cancer with different pathological stages

目的:分析糖类抗原19-9、糖类抗原242、癌胚抗原(CEA)检测对不同病理分期胰腺癌的临床诊断价值。方法:选取我院2015年7月至2017年1月收治的106例胰腺癌患者,检测血清CA19-9、CA242、CEA表达水平,比较手术治疗前后及不同临床分期胰腺癌患者血清CA19-9、CA242、CEA差异,评价上述指标对胰腺癌临床诊断及判断分期的指导作用。结果:胰腺癌病理分期越高,其血清CA19-9、CA242、CEA水平升高越显著,差异有统计学意义(P<0.05)。肿瘤直径≥5 cm者、肿瘤位于胰腺体/尾部者,其血清CA19-9、CA242、CEA均显著高于肿瘤直径<5 cm者及肿瘤位于胰腺头部或全胰腺者,差异有统计学意义(P<0.05)。结论:血清CA19-9、CA242、CEA有助于胰腺癌的临床诊断及分期判断,具有较高的临床价值。

Objective： To analyze the clinical value of carbohydrate antigen 19-9,carbohydrate antigen 242 and carcinoembryonic antigen in different pathological stages of pancreatic cancer. Methods： The levels of serum CA19-9,CA242 and CEA were measured in 106 patients with pancreatic cancer from July 2015 to January 2017.The differences of serum CA19-9,CA242 and CEA in patients with different stages of pancreatic cancer were compared.To evaluate the guiding effect of the above indexes on the clinical stage of pancreatic cancer. Results： The higher the pathological stage of pancreatic cancer,the higher the serum CA19-9,CA242,CEA level,the difference was statistically significant（ P 〈0.05）.Tumor diameter ≥5 cm,the tumor is located in the pancreas / tail,the serum CA19-9,CA242,CEA were significantly higher than the tumor diameter 〈5 cm and the tumor in the pancreas head or pancreas,the difference was statistically significant（ P 〈0.05）. Conclusion： Serum CA19-9,CA242,CEA contribute to the clinical diagnosis and staging of pancreatic cancer,and have high clinical value.