改良GC方案与传统GC方案治疗尿路上皮癌疗效及毒副反应的对比

Comparative of efficacy and toxicity between modified GC regimen and conventional GC regimen in chemotherapy of urothelial carcinoma

目的:比较改良GC方案和传统GC方案在尿路上皮癌化疗中的疗效和毒副反应。方法:本研究选取自2008年12月至2016年6月北京积水潭医院泌尿外科收治的尿路上皮癌患者共70例。38例采用改良GC化疗方案,32例采用传统三周GC化疗方案。所有患者在完成2个周期的化疗后,进行疗效及毒副反应评价。结果:改良GC方案和传统GC方案化疗组患者治疗后总有效率分别为50.0%(19/38)和53.1%(17/32),两组之间的差异无统计学意义(P>0.05);改良GC方案化疗组和传统GC方案化疗组中患者发生Ⅲ-Ⅳ度骨髓抑制的比率分别中15.8%(6/38)和37.5%(12/32),差异有统计学意义(P<0.05);其余毒副反应相比差异均无统计学意义(P>0.05)。结论:在尿路上皮癌患者的化疗中,改良GC化疗方案可以作为传统GC方案的替代在临床中尝试。

Objective： To compare the efficacy and toxicity of modified GC regimen and conventional GC regimen in chemotherapy for patients with urothelial carcinoma. Methods： In this study,70 cases of urothelial carcinoma were selected from December 2008 to June 2016,who were admitted by the Department of Urology,Beijing Jishuitan Hospital.38 patients underwent modified GC chemotherapy and 32 patients received conventional 3-week GC chemotherapy.After two cycles of chemotherapy,the efficacy and toxicities of chemotherapy were evaluated. Results： The total effective rate was 50.0%（19/38） and 53.1%（17/32） in the modified GC regimen and the conventional regimen group.No statistically significant difference was seen between the two groups（ P 〉0.05）.The incidence of grade Ⅲ-Ⅳ haematological toxicity was 15.8%（6/38） and 37.5%（12/32）,respectively,in the modified GC group and the conventional GC group,and the difference was statistically significant（P〈0.05）.There was no significant difference between the two groups in terms of the other side effects（P〉0.05）. Conclusion： Modified GC regimens can be used as alternatives to traditional GC regimens in chemotherapy for patients with urothelial carcinoma.