不同铂类化疗方案辅助治疗老年复发性卵巢癌效果分析

Curative Effect of Different Kinds of Platinum Chemotherapy Plans in Assisted Treatment of Elderly Patients with Recurrent Ovarian Carcinoma

目的探讨奥沙利铂静脉滴注与腹腔灌注方案辅助应用对老年复发性卵巢癌患者疗效及生活质量的影响。方法选取陕西中医药大学第二附属医院2012年3月—2014年3月收治老年复发性卵巢癌100例,按治疗方法分为对照组和观察组,每组50例,分别在多西他赛基础上给予奥沙利铂静脉滴注与腹腔灌注辅助治疗;比较两组客观缓解率、疾病控制率,随访1、2、3年生存率,治疗前后卡洛夫斯基(Karnofsky)评分及毒副反应发生率等。结果观察组客观缓解率和疾病控制率显著高于对照组(P<0.05);治疗后观察组1、2、3年生存率高于对照组(P<0.05);观察组治疗后Karnofsky评分高于对照组、治疗前(P<0.05);观察组骨髓抑制和肝功能损伤发生率均低于对照组(P<0.05)。结论奥沙利铂腹腔灌注方案辅助治疗老年复发性卵巢癌可有效控制疾病进展,提高远期生存率,改善日常生活质量,并有助于预防毒副反应发生,价值优于奥沙利铂静脉滴注。

Objective To investigate curative effect and influence on life quality of Oxaliplatin by intravenous injection and intraperitoneal perfusion in assisted treatment of elderly patients with recurrent ovarian carcinoma. Methods A total of 100 elderly patients with recurrent ovarian carcinoma admitted during March 2012 and March 2014 were divided into control group（ n = 50） and observation group（ n = 50） according to different treatment methods. On the basis of Docetaxel treatment,control group was added with Oxaliplatin by intravenous injection,while observation group was added with Oxaliplatin by intraperitoneal perfusion. Objective remission rate（ ORR）,disease control rate（ DCR）,survival rates of follow-up for 1,2 and 3 years,Karnofsky score（ KPS） before and after treatment and incidence rate of toxic and side effects were compared in two groups. Results In observation group,ORR and DCR values were significantly higher（ P〈0. 05）; survival rates of follow-up for 1,2 and 3 years were significantly higher than those in control group（ P〈0. 05）. KPS score after treatment in observation group was significantly than those in control group and before treatment in observation group（ P〈0. 05）. Incidence rates of bone marrow suppression and liver function damage in observation group were significant lower than those in control group（ P〈0. 05）. Conclusion Oxaliplatin by intraperitoneal perfusion in assisted treatment of elderly patients with recurrent ovarian carcinoma may efficiently control disease progression,improve long-term survival and quality of daily life and help prevent incidence of toxic and side effects,and therefore its value is superior to that by Oxaliplatin intravenous injection.