醋酸亮丙瑞林治疗子宫内膜异位症效果和对氧化应激及炎症反应的影响

Curative Effect of Leuprolide Acetate in Treatment of Patients with Endometriosis and Its Effects on Oxidative Stress and Inflammatory Response

目的探究醋酸亮丙瑞林治疗子宫内膜异位症效果及对氧化应激、炎症反应的影响。方法选取遵化市人民医院接受治疗的子宫内膜异位症60例为观察组,在月经周期开始的1~5 d第1次皮下注射醋酸亮丙瑞林,然后每隔一个月经周期给药1次,连续治疗4个月经周期;此外,选取30例健康体检者作为对照组。评估观察组治疗后疗效;分析观察组治疗前、后血清中氧化应激活性氧(ROS)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)及炎症相关因子变化,并与对照组进行对比。结果观察组治疗有效率为93.3%(P<0.05);观察组治疗前血清中ROS、MDA水平显著升高,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)水平显著降低(P<0.05),观察组血清ROS高于对照组,SOD水平低于对照组(P<0.05)。两组血清MDA和GPx比较差异无统计学意义(P>0.05)。观察组治疗前血清中CRP、TNF-α、IL-1、IL-6水平高于对照组(P<0.05);治疗后观察组血清CRP、TNF-α、IL-1、IL-6水平与治疗前比较下降(P<0.05),血清TNF-ɑ和IL-1β水平仍高于对照组(P<0.05);两组血清CRP和IL-6比较差异均无统计学意义(P>0.05)。结论子宫内膜异位症患者体内处于高氧化应激及高炎症反应状态,醋酸亮丙瑞林治疗能够降低该类患者氧化应激及炎症水平。

Objective To investigate curative effect of Leuprolide Acetate（ LA） in treatment of patients with endometriosis and its effects on oxidative stress and inflammatory response. Methods A total of 60 patients with endometriosis（ observation group） received Leuprolide Acetate subcutaneous therapy at 1-5 days menstrual cycle beginning,then every other menstrual cycle was administered for 1 time,and the therapy was continued for 4 menstrual cycles,and other 30 healthy people taking medical examination were selected as control group. In observation group,curative effect was evaluated; level changes of serum reactive oxygen species（ ROS）,malonaldehyde（ MDA）,superoxide dismutase（ SOD）,glutathion peroxidase（ GPx） and changes of related inflammatory factors were analyzed before and after treatment in observation group,and the values were compared with those in control group. Results Effective rate in observation group was 93. 3%. Compared with those in control group,in observation group,serum ROS and MDA levels were significantly increased,while SOD and GPx levels were significantly decreased before treatment（ P〈0. 05）; after treatment,serum ROS level was significantly higher,while SOD level was significantly lower than those in control group（ P〈0. 05）,but there were no significant differences in serum MDA and GPx levels between two groups（ P〈0. 05）. In observation group,serum C-reactive protein（ CRP）,tumor necrosis factor-ɑ（ TNF-ɑ）,interleukin-1β（ IL-1β） and interleukin（ IL-6） levels were significantly higher before treatment compared with those in control group（ P〈0. 05）,while serum CRP,TNF-ɑ,IL-1β and IL-6 levels after treatment were significantly lower than those before treatment in the same group（ P〈0. 05）,but serum TNF-ɑ and IL-1β levels were still significantly higher than those in control group（ P〈0. 05）,and the differences in serum CRP and IL-6 levels were not statistically significant between two groups（ P〈0. 05）. Conclusion Patients with endometriosis are in high oxidative stress and inflammatory reaction state,and Leuprolide Acetate may reduce levels of oxidative stress and inflammatory factors levels of endometriosis patients.