醒脑静注射液对中重度颅脑损伤患者氧化应激的影响

The effects of the Xingnaojing injection on oxidative stress in patients with severe brain injury

目的:探讨醒脑静注射液对中重度颅脑损伤患者氧化应的影响。方法:将2013年11月-2016年1月在我院接受治疗的60例中重度颅脑损伤患者作为研究对象,并随机分为两组:对照组30例,给予常规治疗;试验组30例,在常规治疗基础上给予醒脑静注射液治疗。对两组患者治疗前后的昏迷评分(GCS评分)、静脉血丙二醛(MDA)、超氧化物歧化酶(SOD)以及肿瘤坏死因子(TNF-α)等指标进行检测并对其临床治疗效果进行综合评价。结果:试验组患者治疗后的GCS评分得到明显改善,显著优于对照组(P<0.05),差异有统计学意义;试验组患者治疗后的MDA、SOD、TNF-α等相关指标与对照组存在明显差异(P<0.05),差异有显著的统计学意义;试验组治疗后有28例患者有效,总有效率为93.3%,显著高于对照组的70.0%(P<0.05)。结论:在常规治疗基础上对中重度颅脑损伤患者给予醒脑静注射液治疗,不仅能显著提高临床疗效,而且对患者的氧化应激状态具有显著的抑制作用。

Objective： To investigate efficacy of the Xingnaojing injection（ 醒脑静注射液） on oxidative stress in patients with moderately severe craniocerebral injury. Methods： 60 patients were divided into two groups, 30 cases in each group. The control group was given conventional treatment; the treatment group took the Xingnaojing injection more. Results： GCS score in the treatment group was obviously improved and significantly better than the control group（P〈0.05）. MDA, SOD, TNF-α exists significant difference between two groups（P〈0.05）. The total efficiency in the treatment group was 93.3% and significantly higher than 70.0% in the control group（P〈0.05）. Conclusion： The Xingnaojing injection plus conventional treatment was effective, and has significant inhibitory effects on the oxidative stress status.