败酱草散对反复上呼吸道感染小儿免疫功能及肠道功能影响的临床研究

Efficacy of Baijiangcao San on immune function and intestinal function in children with recurrent upper respiratory tract infection

目的:探讨败酱草散对反复上呼吸道感染小儿免疫功能及肠道功能的影响。方法:选取我院儿科收治的反复上呼吸道感染患儿162例,按随机数字表法分组,对照组81例予以匹多莫德治疗,研究组81例在对照组基础上予以败酱草散治疗,观察并记录两组间体液免疫功能指标、外周血T淋巴细胞亚群水平、血清炎症因子水平、肠道功能指标,同时比较临床疗效。结果:对照组治疗总有效率(83.95%)低于研究组治疗总有效率(95.06%),差异具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清IgA、IgG、IgM水平较高,治疗后外周血CD3^+、CD4^+T淋巴细胞及CD4^+/CD8^+比值水平较高,CD8^+T淋巴细胞水平较低,治疗后血清TNF-α、IL-6、IFN-γ水平较低,血清IL-2水平较高,治疗后大便性状、排便时长、排便畅否、腹胀频率症状评分较低,差异具有统计学意义(P<0.05)。结论:败酱草散治疗反复上呼吸道感染小儿的临床疗效较好,能有效提高体液免疫及细胞免疫功能,减轻炎症反应,改善患儿肠道功能。

Objective： To investigate the clinical effect of Baijiangcao San（ 败酱草散） on immune function and intestinal function in children with recurrent upper respiratory tract infection. Methods： 162 children were selected and divided into 2 groups. 81 cases in the control group were treated with Pidotimod. 81 cases in the experiment group received Baijiangcao San more. Results： The efficiency in the control group（83.95%） was lower than 95.06% in the experiment group, with a significant difference（P〈0.05）. After treatment, serum levels of IgA、IgG、IgM were higher in the experiment group. Peripheral blood levels of CD3^＋, CD4^＋ T lymphocytes and CD4^＋/CD8^＋ratio were higher than the control group. In the experiment group, CD8^＋ T lymphocytes level was lower; serum levels of TNF-α, IL-6, IFN-γ were lower; serum level of IL-2 was higher; and symptoms scores of stool characteristics, defecation time, defecation, abdominal distension frequency were lower, with significant differences（P〈0.05）. Conclusion： The clinical effect of Baijiangcao San on children with recurrent upper respiratory tract infection was good, can effectively improve the humoral immune and cellular immune function, reduce the inflammatory reaction, improve the intestinal function of children.