逍遥五苓散联合马来酸曲美布汀胶囊治疗腹泻型肠易激综合征44例临床观察

Observation on treating IBS of diarrhea type with Xiaoyao Wuling San plus trimebutine maleate capsule

目的:观察逍遥五苓散联合马来酸曲美布汀胶囊治疗腹泻型肠易激综合征的临床疗效。方法:将80例腹泻型IBS患者随机分为治疗组44例和对照组36例。对照组给予马来酸曲美布汀胶囊每次0.2g,每日3次,饭前30min口服。治疗组在对照组基础上加逍遥五苓散煎剂,两日一剂,饭后服用。两组患者均治疗4周后观察临床疗效,并比较两组治疗前后中医症状(腹痛,腹泻次数,大便形状,粘液便)积分。结果:治疗组临床疗效总有效率为95.45%,对照组为86.11%,两组比较差异有统计学意义(P<0.05)。结论:逍遥五苓散联合马来酸曲美布汀胶囊治疗腹泻型IBS患者可明显改善临床症状,提高临床疗效,改善患者生活质量。

Objective： To observe the clinical efficacy of Xiaoyao Wuling San（ 逍遥五苓散） plus trimebutine maleate capsule on IBS of diarrhea type. Methods： 80 patients were randomly divided into the treatment group of 44 cases and control group of 36 cases. The control group was given the trimebutine maleate capsule, 0.2 g a time, 3 times daily, 30 minutes before meals, orally. The treatment group was given Xiaoyao Wuling San more, a dose for two days after meals. The score of TCM symptoms（abdominal pain, number of diarrhea, stool shape, mucus） and clinical efficacy in two groups were compared before and after 4 course. Results： The total efficiency in the treatment group and control group was 95.45% and 86.11% respectively, with a statistically significant difference, P〈0.05. Conclusion： Xiaoyao Wuling San plus trimebutine maleate capsule on IBS of diarrhea type can improve clinical efficacy and life quality.