小儿支原体肺炎采用阿奇霉素与红霉素治疗临床疗效及安全性分析

Analysis of Clinical Curative Effect and Safety of Azithromycin and Erythromycin in Treatment of Mycoplasma Pneumonia in Children

目的观察小儿支原体肺炎应用阿奇霉素与红霉素治疗的临床效果,并分析其安全性。方法选取该院2015年2月—2016年8月期间所收治的98例小儿支原体肺炎患儿作为该次研究病例,按照治疗手段的不同将其分为研究组和对照组,每组各49例,对照组行常规治疗基础上行红霉素静脉滴注治疗,研究组患儿在常规治疗基础上行阿奇霉素静脉滴注治疗,对比分析两组患儿的临床疗效,不良反应发生情况,并比较两组的症状消失时间。结果研究组患儿的总有效率为95.91%,显著高于对照组(77.55%),咳嗽时间(6.48±0.11)h与发热症状消失时间(3.51±0.19)h明显短于对照组(8.79±0.49)、(6.11±0.31)h,研究组有3例患儿出现胃肠道反应,不良反应发生率为6.12%,对照组患儿有2例发生胃肠道反应,4例轻度皮疹,6例静脉刺激,不良反应发生率为24.49%,两组差异有统计学意义(P<0.05)。结论阿奇霉素应用在治疗小儿支原体肺炎中的效果明显,临床疗效显著高于红霉素,其不良反应少,安全性高,值得临床进一步推广应用。

Objective To observe the clinical curative effect and safety of azithromycin and erythromycin in treatment of mycoplasma pneumonia in children. Methods 98 cases of children with mycoplasma pneumonia admitted and treated in our hospital from February 2015 to August 2016 were selected and divided into two groups with 49 cases in each according to different treatment means, the control group used the intravenous drip treatment of erythromycin on the basis of the routine therapy, while the research group used the intravenous drip of azithromycin on the basis of the routine therapy, and the clinical curative effect, occurrence of adverse reactions and disappearance time of symptoms were compared between the two groups. Results The total treatment effective rate in the research group was obviously higher than that in the control group（95.91% vs 77.55%）, and the cough time and disappearance time of fever in the research group were obviously shorter than those in the control group[（6.48±0.11）h,（3.51±0.19）h vs（8.79±0.49）h,（6.11±0.31）h],and in the research group, there were 3 cases with gastrointestinal reaction, and the incidence rate of adverse reactions was 6.12%, and in the control group, there were 2 cases with gastrointestinal reaction, 4 cases with mild rash and 6 cases with intravenous stimulation, and the incidence rate of adverse reactions was 24.49%, and the difference was obvious, with statistical significance（P〈0.05）. Conclusion The effect of azithromycin in treatment of mycoplasma pneumonia in children is obvious, and the clinical curative effect is obviously higher than that of erythromycin, with few adverse reactions and high safety, and it is worth further promotion and application.