踝臂指数与冠心病患者冠状动脉病变的相关性研究

Relationship of Ankle-brachial Index and Severity of Coronary Atherosclerosis Lesions

目的探讨踝臂指数(ABI)与冠心病(CHD)患者冠状动脉病变严重程度的相关性。方法根据冠状动脉造影检查(CAG)结果将967例患者分为CHD组(432例)和非CHD组(535例),均完善病史采集、血液生化检查及踝臂指数(ABI)检测,分析ABI对冠状动脉病变的预测价值。结果CHD组与非CHD组患者ABI值异常率比较差异有统计学意义(P<0.05);非CHD组与CHD组患单支病变、双支病变、3支病变患者的ABI异常率,两两比较差异均有统计学意义(均P<0.05);CHD组患者的ABI值明显低于非CHD组,CHD组中3支病变患者的ABI值明显低于单支病变组和双支病变组,两组比较差异均有统计学意义(均P<0.05);将入选患者的ABI值与Gensini评分进行直线相关性分析,结果显示CHD组患者ABI值与Gensini评分成负相关,其中3支病变组患者ABI值与Gensini评分成显著负相关。结论 ABI与冠状动脉病变支数及程度密切相关,可作为冠状动脉病变严重程度的指标和用于CHD高危人群的筛查。

Objective To explore the correlation of ankle-braehial index（ ABI） and severity coronary atherosclerosis lesions.Methods According to the coronary artery angiography,967 patients were divided into coronary artery disease（CHD） groups（432 cases） and no-CHD groups（535 cases）,All patient recieved consummate history,blood biochemistry and ABI tested,To observe the value of predict the severity of coronary atherosclerosis by ABI.Results CHD group and CHD group of patients with ABI abnormal rate was statistically significant（P〈0.05）; non CHD group and CHD group with single vessel disease,double vessel lesions,3 lesions in patients with abnormal rate of ABI was 22,there were significant differences（P〈0.05）;patients in group CHD ABI was significantly lower than that in non CHD group,3 lesions in patients with ABI in CHD group was significantly lower than that of single and double vessel lesions groups,significant differences between the two groups（P〈0.05）;the patients ABI value and Gensini score by linear correlation analysis,the results show that the CHD group of patients with ABI was the negative correlation with the Gensini score,of which 3 lesions group ABI patients were negatively correlated with Gensini score.Conclusion There is strong correlation between ABI and the severity of coronary atherosclerosis.And ABI may be helpful to predict the severity of coronary atherosclerosis and used for screening high risk population of CHD.