伴有钙化的T1乳腺浸润性导管癌的病理特征及预后分析

Analysis of pathological features and prognosis of T1 invasive ductal breast carcinoma with calcification

目的探讨伴有钙化的T1乳腺浸润性导管癌的病理特征及预后的影响因素。方法回顾性分析2012年6月至2013年6月该院收治的初治可手术的172例乳腺癌患者的临床病理资料及随访资料,根据乳腺X线图像特征分为钙化组与非钙化组,分析其病理特征之间的差异、影响钙化存在的相关因素和钙化的表达与患者生存之间的关系。结果钙化组患者在病理类型、淋巴结转移、Her-2过表达、TNM分期、Ki-67与非钙化组比较差异有统计学意义(P<0.05),多因素分析显示病例类型、淋巴结转移和Ki-67是影响钙化表达的相关风险因素(P<0.05)。钙化组和非钙化组3年无病生存率分别为87.30%、95.06%,淋巴结转移和钙化是影响乳腺浸性导管癌无病生存时间的独立预后危险因素(P<0.05)。结论钙化是乳腺X线可见的T1乳腺浸润性导管癌预后的危险因素。

Objective To explore the pathological characteristics and prognostic influencing factors of T1 invasive ductal breast carcinoma with calcification. Methods The clinicopathological and follow-up data in 172 patients with initially treated operable T1 invasive ductal breast cancer in this hospital from June 2012 to June 2013 were analyzed restrospectively.The patients were divided into the calcification group and non-calcification group based on the breast X-ray image features.The differences of pathological characteristics between two groups,related factors,and relationship between the calcification expression with patient survival were analyzed. Results The pathological types,lymph node metastasis,Her-2 overexpression,TNM stage and Ki-67 had statistically significant difference between the calcification group and non- calcification group（ P 〈0.05）.The multivariate analysis showed that the cases type,lymph node metastasis and Ki-67 were the related risk factors affecting the calcification expression（ P 〈0.05）.The 3-year disease-free survival rate in the the calcification group and non- calcification group were 87.30% and 95.06% respectively.The lymph node status and calcification were the independent predictive risk factors affecting the disease-free survival time of invasive ductal breast carcinoma（ P 〈0.05）. Conclusion Calcification is visible X-ray risk factor of T1 invasive ductal breast carcinoma prognosis.