溃疡性结肠炎内镜下评分与临床及实验室炎症指标相关性研究

Study on correlations between ulcerative colitis endoscopic index of severity with clinical and laboratory inflammation indicators in ulcerative colitis

目的探讨溃疡性结肠炎(UC)患者内镜下严重性评分(UCEIS)与临床及实验室炎症指标的相关性。方法检测50例UC患者与20例健康对照者外周血炎症相关指标[白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(Hb)、血沉(ESR)、C反应蛋白(CRP)、清蛋白(Alb)],以及临床活动性评分(简化的Mayo评分),并与UCEIS进行相关性分析。结果 UC患者WBC、PLT、CRP和ESR均明显高于健康对照组,Hb和Alb低于健康对照组,差异有统计学意义(P<0.05);UCEIS和WBC、ESR、CRP及简化的Mayo评分呈正相关,和Alb呈负相关(P<0.05),而与Hb和PLT无明显相关性(P>0.05)。结论可通过监测WBC、ESR、CRP、Alb水平和简化的Mayo评分评估病情转归。

Objective To investigate the correlation between the Ulcerative Colitis Endoscopic Index of Severity （UCEIS） with clinical and laboratory inflammation indicators in the patients with ulcerative colitis （UC）. Methods The levels of peripheral blood inflammation related indicators white blood cell （WBC） count,platelet （PLT） count,hemoglobin （Hb）,erythrocyte sedimentation rate （ESR）,C-reactive protein （CRP） and albumin （Alb）,and clinical activity score （simplified Mayo score） were detected in 50 patients with UC and 20 healthy controls.Then the correlation between the results with UCEIS was performed. Results The WBC count,PLT count,CRP and ESR in the UCgroup were significantly higher than those in the control group,while the Hb and Alb levels were lower than those in the control group （P 〈0.05）.UCEIS was positively correlated with WBC count,ESR and CRP levels,and simplified Mayo score,and was negatively correlated with the Alb level （P 〈0.05）,however,UCEIS had no correlation with Hb level and PLT count （P 〉0.05）. Conclusion The condition and outcome of UC can be evaluated by monitoring WBC count,levels of ESR,CRP and Alb,and Mayo score.