摘要
目的观察透明质酸钠联合塞来昔布治疗老年膝骨关节炎(KOA)的疗效及对C反应蛋白(CRP)水平的影响。方法 70例老年KOA患者,随机分为研究组对照组,各35例。对照组单纯口服塞来昔布胶囊治疗,研究组在对照组基础上给予患者膝关节腔注射透明质酸钠,比较两组患者治疗前后症状评分、血清CRP,临床疗效及不良反应。结果对照组治疗后静息疼痛评分、活动疼痛评分、关节压痛评分、关节肿胀评分、血清CRP分别为(0.80±0.14)分、(1.35±0.30)分、(0.93±0.20)分、(0.44±0.22)分、(7.69±2.39)ng/L,均低于治疗前的(1.88±0.71)分、(2.25±0.50)分、(1.84±0.60)分、(0.86±0.20)分、(11.53±2.08)ng/L,差异具有统计学意义(P<0.05);研究组治疗后静息疼痛评分、活动疼痛评分、关节压痛评分、关节肿胀评分、血清CRP分别为(0.42±0.20)分、(0.62±0.30)分、(0.41±0.22)分、(0.22±0.10)分、(4.22±2.28)ng/L,均低于治疗前的(1.84±0.80)分、(2.28±0.44)分、(1.80±0.65)分、(0.85±0.24)分、(11.70±2.25)ng/L,且治疗后研究组各指标水平均低于对照组,差异均具有统计学意义(P<0.05)。研究组治疗5周后及末次随访的有效率分别为88.57%、85.71%,均明显高于对照组的45.71%、48.57%,差异具有统计学意义(P<0.05)。两组不良反应发生率均为5.71%(2/35),比较差异无统计学意义(P>0.05)。结论口服塞来昔布治疗老年KOA的基础上在膝关节腔注射透明质酸钠能够有效缓解疼痛及肿胀等症状,抑制炎症反应,提高临床疗效。
Objective To observe the effect of sodium hyaluronate combined with celecoxib on senile knee osteoarthritis(KOA) and its effect on C-reactive protein(CRP) level. Methods A total of 70 senile knee osteoarthritis patients were randomly divided into research group and control group, with 35 cases in each group. The control group was treated with oral administration of celecoxib capsules, and the research group was treated with knee joint injection of sodium hyaluronate on the basis of the control group. Comparison were made on symptom score and serum CRP before and after treatment, clinical efficacy and adverse reactions between the two groups. Results The control group had rest pain score, active pain score, joint tenderness score, joint swelling score, serum CRP after treatment as(0.80±0.14) points,(1.35±0.30) points,(0.93±0.20) points,(0.44±0.22) points and(7.69±2.39) ng/L, which were all lower than(1.88±0.71) points,(2.25±0.50) points,(1.84±0.60) points,(0.86±0.20) points, and(11.53±2.08) ng/L before treatment the difference was statistically significant(P〈0.05). The research group had rest pain score, active pain score, joint tenderness score, joint swelling score, serum CRP after treatment as(0.42±0.20) points,(0.62±0.30) points,(0.41±0.22) points,(0.22±0.10) points, and(4.22±2.28) ng/L, which were all lower than(1.84±0.80) points,(2.28±0.44) points,(1.80±0.65) points,(0.85±0.24) points and(11.70±2.25) ng/L before treatment the difference was statistically significant(P〈0.05). The research group was better than the control group after treatment, and the difference was statistically significant(P〈0.05). After 5 weeks of treatment and at the end of follow-up, the research group had obviously higher effective rate as 88.57% and 85.71% than 45.71% and 48.57% in the control group, and their difference was statistically significant(P〈0.05). Both groups had incidence of adverse reactions as 5.71%(2/35), and the difference was not statistically significant(P〈0.05). Conclusion On the basis of oral administration of celecoxib in treating senile knee osteoarthritis, knee injection of sodium hyaluronate can effectively relieve the symptoms of pain and swelling, inhibit the inflammatory reaction and improve the clinical efficacy.
作者
蔡沁
朱博武
章歆
丁志军
CAI Qin, ZHU Bo-wu, ZHANG Xin, et al. (Department Eight of Orthopedics, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen 529000, China)
出处
《中国现代药物应用》
2018年第10期92-94,共3页
Chinese Journal of Modern Drug Application
关键词
膝骨关节炎
透明质酸钠
塞来昔布
C反应蛋白
疗效
老年
Knee osteoarthritis
Sodium hyaluronate
Celecoxib
C-reactive protein
Efficacy
Senile