丹红注射液联合阿托伐他汀钙治疗糖尿病合并脑梗死的疗效观察

Efficacy of Danhong Injection combined with atorvastatin calcium for diabetes mellitus complicated with cerebral infarction

目的探讨丹红注射液联合阿托伐他汀钙治疗糖尿病合并脑梗死的临床疗效。方法将100例糖尿病合并脑梗死患者按随机数字表分为研究组和对照组,每组50例。在常规治疗基础上,对照组给予阿托伐他汀钙治疗,研究组给予丹红注射液联合阿托伐他汀钙治疗。比较两组患者血液流变学指标、治疗总有效率、神经功能缺损程度评分及不良反应发生情况。结果治疗后,研究组患者的高切全血黏度、低切全血黏度、血浆黏度及纤维蛋白原水平均低于对照组,治疗总有效率高于对照组,神经功能缺损程度轻于对照组(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹红注射液联合阿托伐他汀钙治疗可以改善糖尿病合并脑梗死患者血液流变学及神经功能,提高临床疗效。

Objective To investigate the clinical efficacy of Danhong Injection combined with atorvastatin calcium for diabetes mellitus complicated with cerebral infarction. Methods One hundred patients with diabetes mellitus complicated with cerebral infarction were divided into study group and control group according to random number table,with 50 cases in each group. The patients in both groups were given conventional treatment,besides,the control group was treated with atorvastatin calcium,and the study group with Danhong Injection plus atorvastatin calcium. The hemorheology indicators,total effective rate of treatment,scores of neurological defects,and incidence of adverse reactions were compared between the two groups. Results After treatment,the levels of high-cut whole blood viscosity,low-cut whole blood viscosity,plasma viscosity and fibrinogen in the study group were all lower than those in the control group,the total effective rate of treatment in the study group was higher than that in the control group,the severity of neurological defects in the study group was milder than that in the control group（ all P〈 0. 05）. No statistically significant difference was found in the incidence rate of adverse reactions between the two groups（ P〉 0. 05）. Conclusion For patients with diabetes mellitus complicated with cerebral infarction,Danhong Injection combined with atorvastatin calcium can improve hemorheology indicators and neurological function as well as increase clinical efficacy.