衣原体毒力因子研究进展

Progress on Virulence Factors of Chlamydia

衣原体(Chlamydia)是一类专性细胞内寄生、具有独特的双相型发育周期的原核微生物,对人和多种畜禽有致病性。研究表明,衣原体的致病性是其毒力因子与宿主细胞的相互作用导致。论文通过对国内外许多学者关于衣原体致病机制和毒力因子的研究进行总结梳理,阐述主要外膜蛋白(MOMP)、多形态膜蛋白(Pmps)、Ⅲ型分泌系统(T3SS)、脂多糖(LPS)、热休克蛋白(HSP)、质粒和蛋白酶样活性因子(CPAF)在衣原体的致病性方面发挥的主要作用。

Chlamydiais an obligate intracellular bacterium characterized by a unique biphasic developmental life cycle,which is pathogenic to human and many kinds of animals.Research suggests that the pathogenicity of Chlamydiais caused by the interaction of virulence factors with host cells.By summarizing the researches on the pathogenic mechanisms and virulence factors of reported by Chlamydia many scholars at home and abroad,this paper expounded that the virulence factors,major outer membrane protein（MOMP）,polymorphic membrane protein（Pmps）,type III secretion system（T3 SS）,lipopolysaccharide（LPS）,heat shock protein（HSP）,plasmid and protease-like activity factor（CPAF）,play major the roles in pathogenicity of Chlamydia.