肠内营养支持的不同时间对急性重症胰腺炎临床疗效的观察

Effect of Enteral Nutrition Support on Clinical Efficacy of Acute Severe Acute Pancreatitis at Different Times

目的:比较急性重症胰腺炎患者两种不同给药时间开始肠内营养支持的临床疗效。方法:选取急性重症胰腺炎患者55例,随机分为2组,分别于入院后24 h内和24~72 h内启动肠内营养支持,观察其血清白蛋白、C反应蛋白、血淀粉酶、尿淀粉酶、急性生理与慢性健康评分、序贯器官衰竭评分、病死率、住院天数、局部并发症和全身并发症等指标,对肠内营养两种不同给药时机的临床疗效做出评价。结果:24 h内开始营养支持能够改善疾病严重状态,减轻炎症反应,促进淀粉酶恢复,降低死亡率同时缩短住院时间,与24~72 h内相比具有统计学差异。结论:临床疗效观察显示,早期肠内营养支持,可能会提高患者的生存率,也可缩短患者住院时间,但其具体机制有待进一步研究。

Objective ：In patients with acute severe pancreatitis,the clinical efficacy of enteral nutrition support was compared between two different dosing schedules. Methods ：A total of 55 acute severe pancreatitis patients were randomly divided into 2 groups. Enteral nutrition support was started within 24 hours and 24 to 72 hours after admission respectively. Serum albumin,C-reactive protein,blood amylase,urine starch Enzyme,acute physiology and chronic health score,sequential organ failure score,case fatality rate,hospitalization days,local complications and systemic complications were evaluated. The clinical efficacy of two different timing of administration of enteral nutrition was evaluated. Results ： Nutritional support started within 24 hours can improve the severity of the disease,reduce inflammation, promote amylase recovery, reduce mortality and shorten the hospital stay,and within 24~72 h compared with a statistically significant difference. Conclusion ：The earlier the time of enteral nutrition support,the higher the survival rate of patients and the shorter the hospitalization time, but the mechanism needs further study.