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艾拉莫德对类风湿关节炎患者Th17细胞与Treg细胞失衡的调节作用 被引量:6

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摘要 目的探讨艾拉莫德对类风湿关节炎患者17型辅助性T细胞(Th17)与调节性T细胞(Treg)失衡的调节作用。方法选取2016年6月至2017年1月住院的活动期类风湿关节炎患者74例,随机分为A组44例和B组30例。B组给予安慰剂口服,A组给予艾拉莫德口服,两组均坚持服药24周。采用流式细胞术检测外周血Th17和Treg细胞比例;采用酶联免疫吸附技术检测血浆Th17和Treg细胞分泌的相关细胞因子;治疗前后对患者进行DSA28,ACR20,ACR50和ACR70等综合疾病临床评分。结果 A组治疗24周后DSA28评分较治疗前有明显改善,差异有统计学意义(P<0.05);治疗24周后A组DSA28评分及ACR20,ACR50,ACR70改善情况均优于B组,差异有统计学意义(P<0.05)。治疗24周后,A组外周血中Th17细胞(CD4+IL-17+)比例相较于治疗前降低,但差异无统计学意义(P>0.05),而Treg细胞(CD4+CD25+)比例相较于治疗前显著升高,差异有统计学意义(P<0.05);治疗24周后,B组外周血中Th17细胞比例无明显改变,Treg细胞比例略有升高,但与治疗前比较,差异无统计学意义(P>0.05)。治疗24周后,A组促炎细胞因子IFN-γ、TNF-α、IL-17A水平较治疗前显著降低,差异有统计学意义(P<0.05);治疗24周后,B组促炎细胞因子IFN-γ、TNF-α、IL-17A水平较治疗前升高,差异有统计学意义(P<0.05)。结论艾拉莫德可通过下调Th17细胞,上调Treg细胞来恢复类风湿关节炎患者内环境细胞稳态,从而缓解疾病进展。
出处 《医疗装备》 2018年第10期6-8,共3页 Medical Equipment
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