TURBT术后沙培林膀胱灌注治疗高危非肌层浸润性膀胱癌疗效观察

Observation of intravesical instillation with picibanil by turns for high-risk non-muscle-invasive bladder cancer after TURBT

目的探讨等离子经尿道膀胱肿瘤电切术(TURBT)结合沙培林膀胱灌注治疗高危非肌层浸润性膀胱癌的临床疗效。方法对31例高危非肌层浸润性膀胱癌患者,采用TURBT术后即刻和后续定期膀胱灌注沙培林治疗,观察治疗疗效。结果所有患者手术顺利,手术时间为(35.25±3.40)min,无输尿管开口损伤,无膀胱穿孔。随访6~18个月,中位时间12.7个月,肿瘤复发率为9.7%,术后膀胱灌注并发症发生率为29.0%。结论 TURBT联合沙培林膀胱灌注治疗高危非肌层浸润性膀胱癌的疗效确切、安全,有较高临床应用价值。

Objective To investigate the effect of intravesical instillation of picibanil for patients with high-risk non-muscle-invasive bladder cancer（NMIBC）after transurethral resection of bladder tumor（TURBT）. Methods Thirty-one patients of NMIBC were chosen randomly to be treated with TURBT,meanwile,bladder instillation of picibanil was performed on the patients regularly.The results were observed. Results The average time of all the operations（35.25±3.40）min.No ureteral openings injuries or vesical perforation were found.The follow-up time was 6-18 months.The median time was 12.7 months.Tumor recurrence was found in 9.7% of the patients,and complication rate of postoperative intravesical instillation was 29.0%. Conclusions Intravesical instillation with picibanil is effective and safe for high-risk NMIBC after TURBT.