摘要
亚铁血红素(Heme或Heam)是一种铁卟啉复合物,是铁在体内最主要的存在方式,也是病原菌生存所需的主要铁离子来源,在细菌感染过程中可导致宿主氧化损伤、细胞死亡、器官功能衰竭、扩大炎症反应等。本文从Heme的结构、来源以及在微生物存活和感染过程中发挥的作用等方面进行综述,以更好地了解细菌的生长和致病过程。
Heme (heam) is a kind of iron porphyrin complexes. It is the most presence of iron in human bodies and also the main source of iron for pathogenic bacteria. Heme causes oxidative damage, cell death and organ failure and promotes inflammation in bacterial infection. This article will review the structure and sources of heme and its role in the process of bacterial growth and infection.
作者
义玉思
严杰
林旭瑷
Yi Yusi, Yan Jie, Lin Xu'ai(Department of Medical Microbiology and Parasitology, School of Medicine , Zhefiang University, Hangzhou 310058, Chin)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2018年第3期226-231,共6页
Chinese Journal of Microbiology and Immunology
基金
浙江省自然科学基金(Y17H190013)