山西省某医院儿科超说明书用药调查分析

Surveillance and analysis of pediatric off-label drug use in a hospital of Shanxi Province

目的研究2015年山西省某医院儿科门诊超说明书用药现状,分析原因并提出建议,促进儿童合理用药。方法随机抽取该院2015年1~12月儿科门诊处方,采用Excel软件录入信息,根据药品说明书,判别其是否存在超说明书用药情况。结果 600张处方中包含用药记录828条。呼吸系统疾病构成比最大(60.17%),超说明书用药发生率为34.07%。前10位的呼吸系统疾病用药中,超说明书用药发生率前三位的是利巴韦林喷雾剂(100.00%)、注射用阿莫西林钠克拉维酸钾(88.24%)、小儿定喘口服液(70.59%)。结论应加强该院儿科门诊呼吸系统疾病用药管理,尤其是雾化、抗菌药物以及中成药的应用。

Objective To study the current status of off-label drug use in a pediatric outpatient clinic in a hospital of Shanxi province in 2015, to analyze the causes and propose recommendations to promote rational use of drugs by children. Methods The pediatric outpatient prescriptions were randomly selected from January to December 2015 in this hospital. The information was entered using Excel software. According to the drug instruction manual, whether there was any off-label drug use was determined. Results The 600 prescriptions contained 828 medication records. The proportion of respiratory diseases was the highest （60.17%）, and the incidence of off-label drug use was 34.07%. Among the top 10 respiratory disease medications, the drugs with top three incidences of off-label drug use were ribavirin spray（100.00%）, amoxicillin clavulanate potassium（88.24%） and children＇s Dingchuan oral liquid（70.59%）. Conclu- sion The drug use management of respiratory diseases in the pediatric outpatient clinic, especially the management of aerosolized, antibacterial drugs and proprietary Chinese medicines should be strengthened.