太赫兹光谱技术在细胞及组织检测中的应用

Application of terahertz spectroscopy in the detection of cell and tissue

太赫兹（terahertz,THz,1THz=10^12Hz）光谱技术作为一种新兴的、无标记、非侵入性的检测方法,已广泛应用于多个领域的研究中.在生物医学领域,THz光谱的独特优势显示了其在实时检测活细胞及组织中有着诱人的发展前景.在细胞检测中,其应用在以下几个方面有了较大发展：细菌细胞的鉴别、肿瘤细胞的鉴定和血细胞的检测.在组织检测中,THz光谱技术显示了其在活组织实时监测和疾病快速诊断中的潜力.并且,将THz光谱及THz成像结合于同一系统能够为组织检测增加敏感性并提供更加综合性的信息.然而,一些技术瓶颈的存在是实现THz波谱技术应用于临床亟需解决的问题.本文着重介绍了太赫兹波谱技术在细胞及组织检测中的应用现状,进一步讨论了面临的挑战及机遇,以期加速其在临床的实际应用.

As a novel,label-free and non-invasive detection modality,terahertz（THz,1THz=1012 Hz）spectroscopy has been widely used in various areas.For instance,in the biomedical field,it has great potentials to provide real-time scanning of living cells and tissues due to its unique advantages.Significant achievements have been reached in cell detection, related to bacterial identification, cancer cell characterization and blood cell detection.In tissue detection, the THz spectroscopy can be used to provide real-time scanning of living tissues and fast diagnosis.Furthermore, a single system which integrated THz spectroscopy and THz imaging would be able to collect information more sensitive and comprehensive. However,the clinical adaption of THz spectroscopy is still a controversial issue attributed to some intrinsic limitations and technical bottlenecks.In this article, both the application of THz spectroscopy in cell and tissue detection and the existing challenges and strategies to accelerate clinical applications were reviewed comprehensively.