综合康复疗法联合解郁安神颗粒干预对产后抑郁的疗效分析

Analysis of the effect of comprehensive rehabilitation therapy combined with jieyu anshen particle in treating postpartum depression

目的观察综合康复疗法联合解郁安神颗粒干预对产后抑郁的疗效以及对血清中瘦素水平的影响。方法选择110例产后抑郁产妇为研究对象,根据住院号单双数分为对照组与综合组,其中对照组给予包括心理干预和放松训练的综合康复疗法,综合组在对照组基础上服用解郁安神颗粒治疗,两组连续治疗8周。比较治疗前、后两组汉密尔顿抑郁量表-17(HAMD-17)评分、匹兹堡睡眠质量指数(PSQI)评分、爱丁堡产后抑郁量表(EPDS)评分及抑郁自评量表(SDS)评分。检测并比较两组血清瘦素水平。结果治疗后,综合组HAMD量表各因子评分[焦虑(2.97±0.33)分、昼夜(0.68±0.09)分、睡眠障碍(2.21±0.24)分、体质量(0.20±0.04)分、绝望感(2.09±0.23)分、认知障碍(6.17±0.08)分、阻滞(4.68±0.07)分]明显低于对照组[焦虑(4.12±0.62)分、昼夜(1.17±0.15)分、睡眠障碍(3.61±0.43)分、体重(0.71±0.09)分、绝望感(3.88±0.46)分、认知障碍(8.15±1.02)分、阻滞(7.30±0.09)分](P<0.01)。治疗4周和8周后,综合组患者的PSQI[(7.52±0.09)分、(5.99±0.07)分]、EPDS[(13.32±1.66)分、(11.77±1.37)分]及SDS[(54.88±6.27)分、(43.30±4.86)分]评分显著少于对照组同期(P<0.01)。治疗后4周和8周,综合组患者血清中瘦素水平[(361.34±38.26)pg·m L-1、(291.63±32.08)pg·m L-1]显著低于对照组,差异有统计学意义(P<0.01)。结论综合康复疗法联合解郁安神颗粒干预对产后抑郁的疗效显著,抑制患者血清中瘦素水平可能与其治疗效果有关。

Objective To analyze the efficacy of comprehensive rehabilitation therapy combined with Jieyu Anshen Particle in treating postpartum depression and its influence on serum levels of leptin .Methods One hundred and ten patients with postpartum depression were selected and randomly assigned into control group （55 cases） and comprehensive group （55 cases） by odd and even admission numbers.Control group was treated with comprehensive rehabilitation therapy while comprehensive group was given additionally Jieyu Anshen Particle.Both groups were continuously treated for 8 weeks.The Hamilton depression scale-17 （HAMD-17） scores,Pittsburgh sleep quality index （PSQI） scores,Edinburgh postpartum depression scale （EPDS） scores,and self-rating depression scale （SDS） scores were compared between the two groups .Serum level of leptin was detected in both groups .Results After treatment,HAMD scale scores of the comprehensive group were （2.97 ±0.33） for anxiety,（0.68 ±0.09） for day and night,（2.21 ±0.24） for sleep disturb-ance,（0.20 ±0.04） for weight,（2.09 ±0.23） for despair,（6.17 ±0.08） for cognitive impairment,and （4.68 ±0.07） for bloc-king,,which were significantly lower than the control group [anxiety （4.12 ±0.62）,day and night （1.17 ±0.15）,sleep disturbance （3.61 ±0.43）,weight （0.71 ±0.09）,despair （3.88 ±0.46）,cognitive impairment （8.15 ±1.02）,blocking （7.30 ±0.09）] （P 〈0.01）.After 4 weeks and 8 weeks of treatment,PSQI （7.52 ±0.09,5.99 ±0.07）,EPDS （13.32 ±1.66,11.77 ±1.37） and SDS （54.88 ±6.27,43.30 ±4.86） scores were significantly lower in the comprehensive group than in the control group （P 〈0.01）.At 4 and 8 weeks after treatment,serum leptin levels in the comprehensive group [（361.34 ±38.26） pg· mL -1 ,（291.63 ±32.08） pg· mL -1 ] were significantly lower than those in the control group ,and the difference was statistically significant （P 〈0.01）.Conclusions Comprehensive rehabilitation therapy combined with Jieyu Anshen Particle has significant effect on postpartum depression ,and inhibi-tion of serum leptin levels may be related to its therapeutic effect .