128例注射用头孢曲松钠致血尿不良反应回顾性分析

Analysis of 128 Cases of Hematuria Induced by Ceftriaxone Sodium for Injection

目的:探讨头孢曲松钠致血尿的临床特点并分析原因,为临床安全合理用药提供参考。方法:采用回顾性研究方法,对头孢曲松钠所致血尿的128份药品不良反应报告进行统计分析,包括患者性别与年龄、原患疾病、给药剂量、联合用药、临床表现和血尿出现时间及预后等。结果:头孢曲松钠致血尿与患者年龄、性别、给药剂量、联合用药等有关,男性多于女性(1.42∶1),10岁以下年龄段儿童构成比最高(22.66%),超剂量给药(7.81%)、联合使用有肾毒性的药物是出现血尿的风险因素,不良反应以速发型为主(<1 d占64.06%),大多数患者(95.31%)预后良好。结论:充分认识头孢曲松钠致血尿的危害,加强用药监测,积极防治血尿不良反应。

Objective： To investigate the clinical characteristics and causes of hematuria induced by ceftriaxone,and provide references for clinical safe and rational drug use. Methods： A retrospective study was conducted to analyze the adverse drug reactions（ ADR） reports of 128 cases of hematuria induced by ceftriaxone sodium,including the sex and age of the patients,the primary disease,the dosage,the combination of drugs,the clinical manifestation and the time and prognosis of hematuria. Results： The hematuria induced by ceftriaxone was related to patient＇s age,sex,dosage,combination therapy and so on,Males were more than females（ 1. 42 ∶ 1）,the proportion of children under the age of 10 was the highest（ 22. 66%）,high dose（ 7. 81%）,drug combined with renal toxicity was the risk factors for hematuria,the main adverse reaction was the rapid onset（ 64. 06% in 〈1 days）. Most of the patients（ 95. 31%） had the good prognosis. Conclusion： It was important to fully understand the hazards of ceftriaxone induced hematuria,strengthen the monitoring of medication,and actively prevent the adverse reactions of hematuria.