6例替加环素相关性低血糖不良反应文献分析

Analysis on 6 Cases of Hypoglycemic Related to Tigecycline

目的:分析替加环素相关性低血糖不良反应病例及其临床特点,为临床安全用药提供参考。方法:通过检索Medline、Pub Med、Springer数据库,中国学术期刊全文数据库(CNKI)和维普中文科技期刊数据库(VIP),收集替加环素相关性低血糖的不良反应个例报道,并对患者性别、年龄、合并基础疾病、联合用药以及低血糖发生时间、临床表现及预后等进行统计分析。结果:收集整理了6例患者使用替加环素50 mg维持剂量后发生低血糖反应,期间分别合并使用了降糖药、降压药、调血脂药等。低血糖不良反应主要发生在用药后1周内,很可能为替加环素相关性低血糖,且不良反应严重。结论:替加环素相关性低血糖的不良反应较少,但后果严重,应引起临床的重视,尤其是既往有糖尿病的老年患者合并用药时,如必须使用应加强血糖等用药监护,早期发现不良反应并给予对症治疗。

Objective： To analyze the general patterns and characteristics of Hypoglycemic related to tigecycline and provide a reference for safety of clinical medication. Methods： Medline,Pub Med,Springer,CNKI and VIP databases were searched for hypoglycemic induced by tigecycline,and the collected informations like correlation to tigecycline,medication situation,adverse reaction time and glycemia were further analyzed statistically. Results： Totally 6 patients with hypoglycemic after cured by tigecycline 50 mg were collected,who respectively taken antihypertensive drugs,hypoglycemic agents and lipid regulating agent. The hypoglycemia was mostly appeared in a week,and probably was iuduced by tigecycline. The adverse reactions（ ADR） were severe. Conclusion： Hypoglycemic induced by tigecycline should be awere,especially in the elderly who had diabetes. Monitoring should be strengthened like glycemia in order to cure hypoglycemic immediately in these people.