摘要
G protein-coupled receptors (GPCRs), also known as seven-transmembrane (7TM) receptors, are crucial components of numerous cellular signaling cascades. There are about 900 GPCRs in the human genome, making GPCRs the largest family of cell-surface receptors (Lappano and Maggiolini, 2011). GPCRs are classified into six classes based on sequence homology and functional similarity: rhodopsin-like receptors (Class A ), the secretin receptor family (Class B), metabotropic glutamate receptors (Class C), fungal mating pheromone receptors (Class D),
G protein-coupled receptors （GPCRs）, also known as seven-transmembrane （7TM） receptors, are crucial components of numerous cellular signaling cascades. There are about 900 GPCRs in the human genome, making GPCRs the largest family of cell-surface receptors （Lappano and Maggiolini, 2011）. GPCRs are classified into six classes based on sequence homology and functional similarity： rhodopsin-like receptors （Class A ）, the secretin receptor family （Class B）, metabotropic glutamate receptors （Class C）, fungal mating pheromone receptors （Class D）.
