药物代谢组学研究现状

Research on pharmacometabolomics

药物代谢组学是代谢组学与药学交叉结合产生的一门新的科学分支，近年来在药物治疗个体化研究领域的应用越来越广泛。其研究过程可大致概括为给药前代谢组学分析、给药后药学分析和统计建模分析3部分。首先基于代谢组学技术对个体给药前生物样本的代谢表型进行分析，全面综合的评估个体差异。随后采用相应药学研究手段对个体给药后的药物反应表型进行分析。最后基于统计建模分析对给药前个体的代谢表型和药物反应表型进行比较来进行药物疗效或毒性评价、预测，为实现个体化医疗提供理论基础。该文通过对近年来国内外文献进行分析总结，详细综述了药物代谢组学在药物体内行为差异预测研究中的应用及其具体的研究流程和方法，为该方法的进一步扩展应用提供思路参考。

Pharmacometabolomics is a new and rapidly growing field in life science, which use metabolomics for studying drug effects and variation in drug response. Recently, it has been widely used in individualized medicine research. The research process of pharmacometabolomic can be divided into three parts ： metabolomic study of baseline samples, drug response analysis after drug admin- istration and statistical analysis. By combining the baseline information on metabotype of an individual with the drug response phenotype after drug exposure, pharmacometabolomic method can be used to predict the efficacy and toxicity of drugs, which providing the theoretical basis for individualized medical treatment. In this paper, we give an overview of present studies in the application of pharmacometabolomics for predicting the individualized drug response. Besides, we also summarized the specific research processes and pharmacometabolomic methods.