ERβ表达与原发性乳腺癌预后的相关性分析

The correlation analysis of ERβ expression in tissues and the prognosis of primary breast cancer

目的探讨雌激素受体β(ERβ)在乳腺癌组织中的表达与原发性乳腺癌综合治疗预后的相关性。方法选取204例雌激素受体阳性、人表皮生长因子受体2(HER2)阴性、淋巴结阳性的乳腺癌患者,全部患者均行乳腺癌改良根治术。术后检测所有患者乳腺癌组织中ERβ的表达水平,并分别给予患者化疗序贯内分泌治疗或单独内分泌治疗,并分析患者的临床特征及生存情况与ERβ在乳腺癌组织中表达水平的相关性。结果对204例患者均术后随访至少1年,患者的1年复发率和死亡率分别为19.1%、7.4%。单因素分析结果显示,1年复发和死亡患者乳腺癌组织中ERβ的表达评分均高于1年未复发和生存的乳腺癌患者,临床分期为Ⅲ期的乳腺癌组织中ERβ的表达评分高于临床分期为Ⅱ期的乳腺癌组织中ERβ的表达评分,差异均有统计学意义(P<0.01);绝经与未绝经患者乳腺癌组织中ERβ的表达评分比较,差异有统计学意义(P<0.05)。经Logistic回归分析显示,生存患者的OR值<0,复发患者的OR值>0;乳腺癌组织中ERβ的表达与乳腺癌患者的生存及复发具有相关性(P<0.05)。结论 ERβ高表达与ER阳性、HER2阴性、淋巴结阳性乳腺癌患者的复发和死亡呈正相关,可能是影响乳腺癌患者预后的危险因素。

Objective To explore the correlation between the expression of ERβ in breast cancer tissues and the prognosis of primary breast cancer with comprehensive treatment. Method A total of 204 cases of breast cancer with positive estrogen receptor（ER）, negative human epidermal growth factor receptor 2（HER2）, and positive lymph node were enrolled. All patients received modified radical mastectomy. The expression level of ERβ in breast cancer tissues was detected after surgery, followed by chemotherapy plus sequential endocrine therapy or endocrine therapy alone. The correlation between the expression level of ERβ in breast cancer tissues and clinical characteristics of breast cancer or survival was analyzed. Result All of the 204 patients were followed for at least 1 year, the 1-year recurrence and mortality rate were 19.1% and 7.4%. In univariate analysis, the expression score of ERβ in breast cancer tissues in patients with recurrence or death within one year was significantly higher than those with non-recurrence or who were survivors, similarly, clinical stage Ⅲ was associated with significantly higher ERβ expression score than stage Ⅱ（P〈0.01）; there was statistically significant difference between premenopausal and postmenopausal patients as well（P〈0.05）. In Logistic regression, survivors had OR〈0, while those with recurrence had OR〉0; the ERβ expression in breast cancer tissues was correlated with the survival and recurrence of breast cancer（P〈0.05）. Conclusion Positive correlation is observed between high expression of ERβ in tissues and recurrence or death in ER positive, HER2 negative, lymph node positive breast cancer, and ERβ may be a risk factor related to prognosis.