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血清维生素D与溃疡性结肠炎相关性系统评价 被引量:1

Relationship between serum vitamin D and ulcerative colitis:a systematic review
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摘要 [目的]对血清维生素D水平与溃疡性结肠炎(ulcerative colitis,UC)的相关性进行探讨。[方法]计算机检索Pubmed、EMbase、Cochrane Library、万方、中国知网、维普等数据库中关于UC患者血清25羟维生素D[25(OH)D]的病例对照研究,应用RevMan5.3、Stata 12.0软件进行Meta分析。[结果]共有11篇文献纳入研究,涉及1 269例研究对象。Meta分析结果显示,UC患者25(OH)D浓度明显低于健康对照组,其标准均数差(standard mean difference,SMD)为-0.49(95%CI:-0.74^-0.24);25(OH)D缺乏检出率的比值比(OR)为1.87(95%CI:1.43~2.45)。[结论]UC患者血清25(OH)D水平低于健康人群。 [Objective]To explore the correlation between serum vitamin D and ulcerative colitis(UC).[Methods]Case-control studies on serum 25-hydroxy vitamin vitamin D[25(OH)D]level in patients with UC were searched in the Pubmed,EMbase,Cochrane Library,Wanfang,CNKI and VIP databases.Meta-analysis was performed using RevMan5.3,Stata12.0.[Results]A total of 11 studies involving 1 296 participations were included.Meta-analysis showed that the serum 25(OH)D levels in patients with UC were significantly lower than those in control group(SMD=-0.49,95%CI:-0.74--0.24,P0.05).The detection rate of 25(OH)D deficiency in patients with UC was significantly higher than that of control group(OR=1.87,95%CI:1.43-2.45).[Conclusion]The serum 25(OH)D levels of patients with UC was lower than those of healthy people.
作者 刘通 张飞越 高攀 费素娟 LIU Tong;ZHANG Fei-yue;GAO Pan;FEI Su-juan(Xuzhou Medical University, Xuzhou 221002, China;Department of Gastroenterology, the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)
出处 《中国中西医结合消化杂志》 CAS 2018年第4期322-327,共6页 Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词 溃疡性结肠炎 25羟维生素D META分析 ulcerative colitis 25 (OH)D meta-analysis
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