血清维生素D与溃疡性结肠炎相关性系统评价

Relationship between serum vitamin D and ulcerative colitis:a systematic review

[目的]对血清维生素D水平与溃疡性结肠炎(ulcerative colitis,UC)的相关性进行探讨。[方法]计算机检索Pubmed、EMbase、Cochrane Library、万方、中国知网、维普等数据库中关于UC患者血清25羟维生素D[25(OH)D]的病例对照研究,应用RevMan5.3、Stata 12.0软件进行Meta分析。[结果]共有11篇文献纳入研究,涉及1 269例研究对象。Meta分析结果显示,UC患者25(OH)D浓度明显低于健康对照组,其标准均数差(standard mean difference,SMD)为-0.49(95%CI:-0.74^-0.24);25(OH)D缺乏检出率的比值比(OR)为1.87(95%CI:1.43~2.45)。[结论]UC患者血清25(OH)D水平低于健康人群。

[Objective]To explore the correlation between serum vitamin D and ulcerative colitis（UC）.[Methods]Case-control studies on serum 25-hydroxy vitamin vitamin D[25（OH）D]level in patients with UC were searched in the Pubmed,EMbase,Cochrane Library,Wanfang,CNKI and VIP databases.Meta-analysis was performed using RevMan5.3,Stata12.0.[Results]A total of 11 studies involving 1 296 participations were included.Meta-analysis showed that the serum 25（OH）D levels in patients with UC were significantly lower than those in control group（SMD=-0.49,95%CI：-0.74--0.24,P0.05）.The detection rate of 25（OH）D deficiency in patients with UC was significantly higher than that of control group（OR=1.87,95%CI：1.43-2.45）.[Conclusion]The serum 25（OH）D levels of patients with UC was lower than those of healthy people.