谷氨酰胺营养支持对胃肠道恶性肿瘤恶液质患者血清细胞因子水平的影响

The clinical effect of Glutamine on the treatment of cytokines in patients of gastrointestinal malignant tumor with cachexia

[目的]探讨谷氨酰胺营养支持治疗应用在胃肠道恶性肿瘤患者中对血清细胞因子的影响和临床应用价值。[方法]选择我院治疗的120例胃肠道恶性肿瘤恶液质患者,采取随机数字表法分为观察组和对照组,每组各60例。对照组给予常规营养支持,观察组在对照组的基础上联合谷氨酰胺营养支持进行治疗,记录2组治疗效果。[结果]观察组治疗后白蛋白(39.77±3.85)g/L、前白蛋白(265.82±34.17)mg/L、总蛋白(64.58±4.65)g/L,对照组治疗后白蛋白(34.63±2.71)g/L、前白蛋白(214.53±21.89)mg/L、总蛋白(60.67±3.15)g/L,组间比较差异有统计学意义(t=8.4565、9.7902、5.3925,P<0.05)。观察组治疗后白细胞介素-8(15.14±1.21)ng/L、肿瘤坏死因子(11.04±1.23)ng/L,对照组治疗后白细胞介素-8(21.36±2.97)ng/L、肿瘤坏死因子(18.79±2.79)ng/L,组间比较差异有统计学意义(t=15.0232、19.6882,P<0.05)。[结论]谷氨酰胺营养支持治疗应用在胃肠道恶性肿瘤恶液质患者中能够有效降低细胞炎性因子浓度,改善患者恶液质状态,值得在临床大力推广使用。

[Objective]To investigate the effect of glutamine nutrition support therapy on serum cytokines levels in patients with gastrointestinal cancer and clinical application value.[Methods]One hundred and twenty patients with gastrointestinal tract malignant tumor and cachexy treated in our hospital were selected in this study.According to the method of random number table,patients were divided into two groups：observation group and control group.Both groups were given routine nutritional support and the observation group treated with glutamine nutrition support on the basis of the above.The curative effect of two groups were recorded.[Results]Albumin in the observation group after treatment（39.77±3.85）g/L,prealbumin（265.82±34.17）mg/L,total protein（64.58±4.65）g/L;Albumin in the control group after treatment（34.63±2.71）g/L,prealbumin（214.53±21.89）mg/L,total protein（60.67±3.15）g/L,comparison between the two groups was statistically significant difference（t=8.4565,9.7902,5.3925,P〈0.05）.The observation group after treatment interleukin 8（15.14±1.21）ng/L,tumor necrosis factor（11.04±1.23）ng/L;The control group after treatment interleukin 8（21.36±2.97）ng/L,tumor necrosis factor（18.79±2.79）ng/L,comparison between groups was statistically significant difference（t=15.0232,19.6882,P〈0.05）.[Conclusion]Glutamine nutrition support therapy applied in patients with gastrointestinal malignant tumor and cachexy can effectively reduce the cell inflammation factor concentration,improve the state of patients with evil fluid to pledge,is worth popularizing in clinical use.