进展期和静止期寻常型银屑病患者Th17细胞表达差异的Meta分析

Difference of Th17 cells level in the patients with psoriasis vulgaris at advanced and quiescent stage: a Meta-analysis

目的:明确寻常型银屑病进展期和静止期患者外周血及皮损组织中Th17细胞表达的差异。方法:电子检索万方、中国知网、维普、CBM、Pub Med、Embase数据库,纳入所有关于进展期和静止期寻常型银屑病与Th17细胞表达关系的病例对照研究。由两名独立的研究员对纳入的文献进行质量评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入12篇文献。Meta分析结果显示进展期银屑病组外周血及皮损组织中Th17细胞的表达高于静止期银屑病组,[SMD=2.15,95%CI(1.28,3.02)]。结论:Th17细胞可能与银屑病的进展相关。

Objective： To determine the association of Th17 cells levels in peripheral blood among the patients with psoriasis vulgaris at active and quiescent stages. Methods： The articles of randomized,controlled clinical trials on Th17 cells level in peripheral blood and lesions of the patients with psoriasis vulgaris at active and quiescent stage were searched in wanfang med online,China national knowledge infrastructure,VIP database for Chinese technical periodicals and CBM,Pub Med and embase. The quality of the articles was assessed by two reviewers and meta-analysis was performed using the Rev Man 5.3 software. Results： A total of 12 articles met the criteria. The results of meta-analysis showed that the levels of Th17 cells in the peripheral blood and lesions in the active group were higher than those in the quiescent group [SMD = 2.15,95% CI(1.28,3.02） ]. Conclusion： The progression of psoriasis may be associated with the Th17 cells level.