辅助生殖技术后代自闭症谱系障碍发病风险的研究进展

Research advance in the risk of autism spectrum disorders in offspring of assisted reproductive technology

辅助生殖技术(assisted reproductive technology,ART)与围产期不良妊娠结局如多胎妊娠、早产、低体质量出生、遗传印记紊乱等密切相关,而上述不良妊娠结局同样是自闭症谱系障碍(autistic spectrum disorder,ASD)发病的危险因素。关于ART与后代ASD发病率之间是否存在关联一直饱受争议,尚无定论。本文对既往观察性研究及系统评价进行综述,以期对两者之间的关系展开初探,为评估ART技术是否对后代长期的神经心理发育造成影响奠定基础。

Assisted reproductive technology （ART） has been closely related to adverse perinatal pregnancy outcomes such as multiple pregnancy, premature birth, low birth weight, genetic imprinting disorders, which were also risk factors of autistic spectrum disorder （ASD）. There has been a controversial issue about whether there was an association between ART and ASD, and the result is still inconclusive. Previous observational studies and systematic reviews have been summarized to expand research on the relationship between ART and ASD and to assess whether ART has bad influence on long-term neuropsychological development.