对于多囊卵巢综合征患者不同内膜准备方案在冻融周期中的应用

Application of endometrial preparation protocols in frozen thawed embryo transfer cycles for polycystic ovary syndrome patients

目的比较多囊卵巢综合征(PCOS)患者不同内膜准备方案对冻融胚胎移植的影响。方法回顾性分析多囊卵巢综合征患者冻融周期中应用激素替代周期组(HRT组:206例)与降调节-激素替代周期组(Gn RHa组:152例)准备内膜其相关妊娠结局。结果两组患者平均年龄、不孕年限、移植日内膜厚度,种植率,移植胚胎数,妊娠率,流产率,宫外孕率,活产率均差异无统计学意义(P>0.05)。反复移植失败的患者所占比例在降调节-激素替代周期组与激素替代周期组相比较多,差异有统计学意义(P<0.05)。结论对于多囊卵巢综合征的患者冻融周期可以考虑应用降调节-激素替代方案,尤其对有反复移植失败病史者,此方案可获得较为理想的妊娠结局。

Objective To investigate the application of endometrial preparation protocols in the frozen thawed embryo transfer(FET） cycles for patients with polycystic ovary syndrome(PCOS）. Methods Retrospective study of the PCOS patients on the clinical results of different endometrial preparation protocols in FET cycles. 358 cycles were divided into hormone replacement treatment group(HRT group,n = 206） and 3. 75 mg Gn RHa combined hormone replacement treatment group(Gn RHa group,n = 152）. Results No significant differences were found between HRT group and Gn RHa group in average age,duration of infertility,endometrial thickness on transfer day,no of embryos transferred,implantation rate,clinical pregnancy rate,abortion rate,ectopic pregnancy rate and live birth rate. In this retrospective study,more patients with repeated failure of embryo transfer in Gn RHa group compared with HRT group(P〈0. 05）,there had significant differences. Conclusion For the PCOS patients,the down regulation combined hormone replacement treatment in the frozen thawed cycles can be an ideal choice,especially for the repeated failure ones.