摘要
除气道炎症和气道高反应性外,气道重塑也是支气管哮喘(简称哮喘)的重要发病机制。气道重塑是哮喘的非特异性炎症改变,可引起持续性气流受限、肺功能下降等,与哮喘的严重程度、疾病进展以及预后密切相关。近年来对气道重塑有了新的探索和发现,本文将对其部分研究进展作一综述。
Airway remodeling is a key pathogenesis of brochial asthma(asthma) in addition to airway inflammation and airway hyperresponsiveness. Airway remodeling is a non-specific inflammatory change of asthma, which can result in persistent airflow limitation and lung function decline. Moreover, airway remodeling is closely related to the severity of asthma, disease progression and prognosis. In recent years, new exploration and discovery have been made for airway remodeling. This article will review some of its research progress.
作者
朱曼旎
吉宁飞
黄茂
Zhu Manni, Ji Ningfei, Huang Mao(Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Chin)
出处
《国际呼吸杂志》
2018年第9期700-703,共4页
International Journal of Respiration
基金
国家自然科学基金面上项目(81770031)
江苏省自然科学基金面上项目(BK20171501)
江苏省卫生计生委面上科研课题(H201501)
关键词
支气管哮喘
气道重塑
进展
Bronchial asthma
Airway remodeling
Progress