蛋白质组学在甲状腺疾病中的研究进展

The progress of proteomics in thyroid diseases

蛋白质组学是在蛋白质的整体水平上进行研究,从而获得关于细胞代谢、疾病发展等过程的全面认识.近几年来,蛋白质组学中差异蛋白质的研究在判断甲状腺结节的良、恶性及了解各种甲状腺疾病的发病机制中发挥日趋重要的作用.研究表明,一些差异蛋白表达的上调可以抑制细胞凋亡及上调细胞凋亡阈值,致使细胞异常增殖及分化,最终导致肿瘤;也可促进自身免疫炎性反应,加重Graves病或桥本甲状腺炎的病情.

Proteomics mainly refers to obtain the comprehensive understanding of the process of cell metabolism and disease development through the research at the overall level of protein.Recently,the differential expression of proteins in proteomics plays an increasingly crucial role in distinguishing benign from malignant thyroid nodules and understanding the pathogenesis of various thyroid diseases.Many studies reveal that the up-regulation of some differentially expressed proteins can inhibit apoptosis and up-regulate the threshold of apoptosis,resulting in abnormal proliferation and differentiation of cells,eventually leading to the development of tumors.Also,such up-regulation can promote autoimmune inflammation,aggravating Graves＇ disease or Hashimoto＇s thyroiditis.