蛙皮素样受体亚型-3与代谢综合征

Bombesin receptor subtype-3 and metabolic syndrome

蛙皮素样受体家族的蛙皮素样受体亚型-3（BRS-3）是一种G蛋白耦联受体,主要存在于中枢神经系统和外周组织.研究发现,BRS-3基因敲除小鼠有糖代谢受损、基础代谢率降低、摄食与吸收增加、体重增加、胰岛素分泌增加、胰岛素抵抗、轻度高血压等一系列代谢性因素的变化.2型糖尿病合并肥胖人群的脂肪细胞、骨骼肌细胞中BRS-3 mRNA与蛋白质表达水平是减少的.研究发现,BRS-3激动剂有刺激胰岛素分泌、增加基础代谢率等作用,从而可能为治疗肥胖、2型糖尿病等代谢性疾病提供一个新思路.

The bombesin-like receptor subtype-3 （BRS-3）,a member of the bombesin-like receptor family,is a G-protein coupled receptor mainly found in the central nervous system and peripheral tissues.The study found that BRS-3 gene knockout mice had impaired glucose metabolism,decreased basal metabolic rate,increased food intake and absorption,weight gain,increased insulin secretion,insulin resistance,mild hypertension and a series of metabolic changes.In patients with type 2 diabetes mellitus and obesity,the expression of BRS-3 mRNA and protein in adipocytes,skeletal muscle cells have decreased.Studies found that BRS-3 agonists could stimulate insulin secretion,increase basal metabolic rate,which may provide a new insight for the treatment of metabolic disease such as obesity,type 2 diabetes.