血糖波动与糖尿病神经病变的关系

Relationship between glycemic variability and diabetic neuropathy

血糖波动是糖尿病慢性并发症的独立危险因素，糖尿病神经病变是糖尿病最常见的慢性并发症，由于具有较高的发病率、致残率和死亡率而一直备受关注。近年来有研究证实，血糖波动与糖尿病神经病变关系密切。血糖波动主要通过激活氧化应激、损伤血管内皮功能以及促发炎性反应等一系列病理生理过程诱导糖尿病神经病变的发生。

Glycemic variability is an independent risk factor for diabetic complications, diabetic neuropathy is the most common chronic complications of diabetes, which has been paid inuch attention to due to its high incidence, disability rate and mortality. In recent years, studies have confirmed that glycemic variability was closely related to diabetic neuropathy. Glycemic variability induces diabetic neuropathy mainly through a series of pathophysiological processes such as activating oxidative stress, damaging vascular endothelial function and promoting inflammatory reaction.