奥拉西坦治疗老年脑出血后认知功能障碍的疗效观察

Analysis of effect of oxiracetam on cognition dysfunction of elderly patients with encephalorrhagia

目的观察奥拉西坦治疗脑出血老年患者认知功能障碍的临床疗效。方法选取2013年5月-2015年5月医院收治确诊的120例脑出血后认知功能障碍患者为研究对象,将其随机分为观察组和对照组各60例。对照组在常规治疗的基础上给予安慰剂,观察组在常规治疗的基础上给予奥拉西坦静脉滴注。比较2组治疗前后蒙特利尔认知评估量表评分(Mo CA评分)和巴氏指数(BI)及不良反应发生率。结果治疗前,2组Mo CA评分及BI比较差异均无统计学意义(P>0.05);治疗1个疗程后,2组患者Mo CA评分及BI与治疗前比较均有明显提高,且观察组治疗后Mo CA评分及BI均显著高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论奥拉西坦在有效改善患者认知功能障碍的同时能提高日常生活能力,且药物不良反应小,适用于老年认知障碍患者。

Objective To observe the clinical efficacy of oxiracetam in treatment of cognitive dysfunction in elderly patients with cerebral hemorrhage. Methods 120 patients with cognitive dysfunction after intracerebral hemorrhage admitted to hospital from May 2013 to May 2015 were selected as the research object,and was randomly divided into the observation group and the control group,with 60 cases in each group. The control group was treated with conventional therapy and placebo. On the basis of routine treatment,the observation group was given intravenous infusion of oxiracetam. The Montreal cognitive assessment scale(MoCA score）,the barson index(BI） and the incidence of adverse reactions between the two groups were compared. Results Before treatment,there was no significant difference of MoCA scores and BI between the two groups(P〉0. 05）.After one course of treatment,the scores of MoCA and BI in the two groups were significantly increased compared with those before treatment,and the MoCA scores and BI in the observation group were significantly higher than those in the control group,the differences were statistically significant(P〈0. 05）. There was no significant difference in the incidence of adverse reactions between the two groups(P〉0. 05）. Conclusion Oxiracetam can effectively improve the cognitive function of patients,improve the ability of daily living,and has little adverse reactions,which is suitable for elderly patients with cognitive dysfunction.