镇喘颗粒联合舒利迭治疗对儿童痰热蕴肺型中重度哮喘干扰素-γ、嗜酸性粒细胞及肺功能的影响

Effect of antiasthmatic granules combined with seretide on interferon-γ,eosinophils,and pulmonary function of children with heat-phlegm type moderate to severe asthma

目的探讨镇喘颗粒联合舒利迭治疗对儿童痰热蕴肺型中重度哮喘干扰素(IFN-γ)、嗜酸性粒细胞(EOS)及肺功能的影响,为儿童中重度哮喘的治疗提供理论依据。方法选取2015年4月-2016年10月绵阳市中心医院儿科门诊诊治的68例哮喘急性发作期患儿作为研究对象,按照1∶1的比例将其随机分成对照组与观察组,每组各34例患儿。对照组患儿给予舒利迭治疗,观察组在此基础上给予镇喘颗粒治疗。检测治疗前及治疗6周后两组患儿血清白细胞介素(IL)水平及外周血白细胞(WBC)、EOS、IgE水平,测定肺功能指标,评定哮喘日间、夜间症状评分,比较临床效果。结果与治疗前比较,两组患儿IL-4、IL-5水平降低,IL-10、IFN-γ水平升高,外周血WBC计数、EOS计数、IgE水平降低,第1 s用力呼吸容积(FEV1)、最大呼气流量(PEF)、用力肺活量(FVC)以及FEV1/FVC肺功能指标升高,哮喘日间、夜间症状评分降低,差异均有统计学意义(P<0.01)。与对照组比较,观察组患儿IL-4、IL5水平较低,IL-10、IFN-γ水平较高,外周血WBC计数、EOS计数、IgE水平较低,FEV1、PEF、FVC以及FEV1/FVC肺功能指标较高,哮喘日间、夜间症状评分较低,总有效率较高,差异均有统计学意义(P<0.05)。结论镇喘颗粒联合舒利迭可有效控制小儿痰热蕴肺型中重度哮喘IFN-γ、EOS水平,提高肺功能,效果显著。

Objective To explore the effect of antiasthmatic granules combined with seretide on interferon-γ(IFN-γ）,eosinophils,and pulmonary function of children with heat-phlegm type moderate to severe asthma,provide a theoretical basis for treatment of moderate to severe asthma in children. Methods From April 2015 to October 2016,68 children with asthma during acute onset phase diagnosed and treated in Outpatient of Pediatrics in Mianyang Central Hospital were selected and divided into control group and observation group,34 children in each group. The children in control group were treated by seretide,and the children in observation group were treated by antiasthmatic granules combined with seretide. The levels of serum interleukins,white blood cell(WBC） and eosinophils counts,the levels of IgE in peripheral blood before treatment and at six weeks after treatment in the two groups were detected. The indexes of pulmonary function were detected,asthma daytime and nighttime symptom scores were obtained, and the clinical effects in the two groups were compared.Results Compared with before treatment,the levels of serum IL-4 and IL-5 in the two groups decreased,while the levels of serum IL-10 and IFN-γincreased,WBC and eosinophils counts,and the levels of IgE in peripheral blood decreased,FEV1,PEF,FVC,and FEV1/FVC increased,asthma daytime and nighttime symptom scores decreased,there were statistically significant differences(P〈0. 01）. Compared with control group,the levels of serum IL-4 and IL-5 in observation group decreased,the levels of serum IL-10 and IFN-γ increased,WBC and eosinophils counts,the level of IgE in peripheral blood was lower,FEV1,PEF,FVC,and FEV1/FVC were higher,asthma daytime and nighttime symptom scores were lower,the total effective rate was higher,there were statistically significant differences(P〈0. 05）. Conclusion Antiasthmatic granules combined with seretide can effectively control the levels of IFN-γ,eosinophils and improve pulmonary function in children with heat-phlegm type moderate to severe asthma,the efficacy is significant.