武汉市武昌区417例婴幼儿接种乙肝疫苗后的乙肝标志物模式分析

Analysis on the modes of hepatitis B virus markers after inoculation of hepatitis B vaccine in 417 infants in Wuchang District,Wuhan city

目的分析武昌区417例24个月内婴幼儿接种乙肝疫苗后乙肝标志物的模式及意义,为临床诊断、分析乙肝病毒感染以及疫苗免疫效果提供重要依据。方法选取2016年1月-2017年8月在该院就诊的年龄0~24个月接种乙肝疫苗后的婴幼儿417例为研究对象,采用酶联免疫法检测婴幼儿乙肝5项指标[乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗体(HBs Ab)、乙型肝炎e抗原(HBeAg)、乙型肝炎e抗体(HBeAb)及乙肝核心抗体(HBcAb)]。结果乙肝血清学标志物共出现7种模式,其中5项全阴者144例,占34.53%;单纯保护性抗体(HBsAb)253例,占60.67%;不同年龄段婴幼儿单纯HBsAb阳性率比较差异有统计学意义(P<0.05),其中7~12个月年龄段婴幼儿单纯HBsAb阳性率为94.85%,明显高于其他年龄段(P<0.05),13~24个月年龄段婴幼儿单纯HBsAb阳性率有所下降,为75.41%;男女婴幼儿单纯HBsAb阳性率比较差异无统计学意义(P>0.05)。结论全程接种乙肝疫苗后应及时检测乙肝标志物,便于后期复种,对于母亲是乙肝携带者的婴幼儿,应加强乙肝标志物的监测。

Objective To analyze the modes of hepatitis B virus(HBV） markers after inoculation of hepatitis B vaccine in 417 infants under 24 months in Wuchang District and the significance,provide an important basis for clinical diagnosis,analysis of HBV infection and effect of HBV vaccine immunity. Methods From January 2016 to August 2017,417 infants under 24 months after HBV vaccine immunity in the hospital were selected,then enzyme-linked immunosorbent assay(ELISA） was used to detect five markers of HBV(HBsAg,HBsAb,HBeAg,HBeAb,and HBcAb）. Results There were 7 modes of HBV serological markers. A total of 144 infants were found with five negative markers,accounting for 34. 53%,253 infants were found with simple protective antibody(HBsAb）,accounting for 60. 67%.There was statistically significant difference in the positive rate of simple HbsAb among the infants in different age groups(P〈 0. 05）,the positive rate of simple HbsAb in infants aged 7-12 months was 94. 85%,which was statistically significantly higher than those in infants in other age groups(P〈0. 05）; the positive rate of simple HbsAb in infants aged 13-24 months decreased to 75. 41%. There was no statistically significant difference in the positive rate of simple HbsAb between boys and girls(P〉0. 05）. Conclusion HBV markers should be detected timely after inoculation of hepatitis B vaccine,which is convenient for revaccination. HBV markers monitoring should be strengthened among the infants whose mothers are HBV carriers.