长五聚蛋白3因子在炎性相关疾病中的作用

Role of long pentraxin 3 in inflammation-related diseases

长正聚蛋白3(long pentraxin 3,PTX3)是一种与C反应蛋白(C-reactive protein,CRP)同属于长正五聚家族成员的新的典型急性期蛋白,参与到炎症、免疫、血管重塑、细胞凋亡等广泛生物效应中。炎性相关疾病是现代社会人群中普遍高发的疾病,如何预防和改善炎症状态,是目前临床上需要攻克的难题。与CRP相比,PTX3能更好地反映出局部炎症,且其生物结构更加稳定,便于检测,有望成为临床上用来对炎症反应进行诊断和治疗的更敏感的生物学指标。

Inflammatory disease is a common and high prevalence of disease in modern society. How to prevent the occurrence of inflammation and improve the inflammatory state is a difficult problem now. Long pentraxin 3 （PTX3） is a new type of acute phase protein, with C-reactive protein （CRP） belongs to the long family of pentamers. PTX3 is involved in inflammation, immunity, vascular remodeling, apoptosis and other biological effects in a wide range. Studies have shown that compared with CRP, PTX3 can more quickly respond to local inflammation, and its biological structure is more stable and easy to detect; it is expected to become more clinically sensitive biological indicators for the diagnosis and treatment of inflammatory response.