肺动脉高压中内皮间质转化信号通路的研究进展

Research progress on the signal pathway of endothelial to mesenchymal transition in pulmonary arterial hypertension

肺血管重塑是肺动脉高压(pulmonary arterial hypertension,PAH)主要的病理机制之一。内皮间质转化(endothelial to mesenchymal transition,EndMT)是肺血管重塑的重要病理基础。目前关于PAH机制的研究主要集中于血管细胞增殖,而涉及EndMT信号通路的研究并未深入。因此,探究肺动脉EndMT的信号机制并进行相应干预研究对治疗PAH起重要作用。

Pulmonary vascular remodeling is the major pathological mechanism in pulmonary arterial hypertension （PAH）, and endothelial to mesenchymal transition （EndMT） plays an important role of this process. Current researches about the molecular mechanisms of PAH mainly focus on cell proliferation, but the specific signal path of EndMT is still not clear. Therefore, an important strategy for the treatment of PAH is to explore the signal mechanism of EndMT in PAH with corresponding targeted intervention.