唾液蛋白质糖基化及其与全身和口腔疾病关系的研究进展

Advances in salivary protein glycosylation and its relationship with systemic and oral diseases

蛋白质糖基化是重要的蛋白质翻译后修饰方式之一,通过赋予蛋白质各种结构和功能特征而在生命活动中扮演重要角色。唾液作为一种获取简单且无创的生理物质,包含有来自血清、龈沟液、口咽黏膜分泌物的成分。近年来随着相关研究的深入,人们对唾液的认识被不断更新。研究发现,唾液蛋白质可以作为一些疾病的诊断指标,唾液中蛋白质糖基化修饰也与多种疾病状态密切相关。本文就唾液蛋白质糖基化及其与全身和口腔疾病关系的研究进展作一综述。

Protein glycosylation is one of the most important protein post-translational modifications that can affect life activities by endowing the protein with various structural and functional features. Saliva is an easy-to-obtain, noninvasive body fluid that contains components originating from serum, gingival crevicular fluid, and oropharyngeal mucosae. In recent years, understanding of saliva has been constantly updated with the developments in related research. Studies have shown that salivary proteins can be used as diagnostic markers for certain diseases, and changes of protein glycosylation in saliva are generally considered to be related to many diseases. In this review, salivary protein glyeosylation and its relationship with systemic and oral diseases were discussed.