动物实验系统评价/Meta分析检索方法的介绍

How to develop the search strategy of systematic reviews/meta-analysis of animal researches:an introduction

目的介绍动物实验系统评价/Meta分析检索策略的制定方法和实施步骤,为国内相关研究人员提供参考依据,促进国内高质量动物实验系统评价/Meta分析的开展和实施。方法计算机检索Pub Med、EMbase和CNKI数据库,搜集与动物实验系统评价/Meta分析检索策略、流程、方法制定和报告等相关的文献,检索时限均从建库至2017年10月。对纳入研究进行描述性分析。结果最终纳入5个研究。动物实验系统评价/Meta分析检索方法的实施过程可归纳为5个步骤:(1)确定/凝练研究问题;(2)选择恰当数据库和其他检索资源;(3)将研究问题转化为检索策略;(4)综合检索结果,去除重复引文;(5)筛选可能符合要求的研究。此外,需要注意从检索方法和检索结果两个方面充分报告其检索策略。结论动物实验系统评价/Meta分析检索方法实施过程分为5个步骤,提供了较为清晰的检索思路,能够帮助动物实验系统评价/Meta分析的研究人员设计、制定、实施较为广泛和全面的检索策略。

Objectives To introduce the formulating methods and implementing steps of search strategy of systematic reviews（SRs）/meta-analysis（MAs） of animal experiments, so as to provide a reference for domestic related researchers, and promote the development and implementation of high quality SRs/MAs of animal experiments in China. Methods Pub Med, EMbase and CNKI databases were searched online to retrieve studies on the search strategy of SRs/MAs of animal experiments from inception to October 2017. A descriptive analysis was then conducted using the evidence-based medicine theory and method. Results A total of 5 studies were included. The 5 basic steps on how to design and carry out comprehensive search strategies to identify potentially relevant animal experiments on a specific research question were as follow： 1） Formulate research question; 2） Identify appropriate databases and sources of studies;3） Transform research question into search strategy; 4） Collect search results and remove duplicates; 5） Identify potentially relevant papers. The report of search strategy needs to state its search method and search results clearly.Conclusion These 5 steps can provide an effective method, which will assist researchers in performing a comprehensive literature search.