细胞膜仿生纳米探针在肿瘤靶向治疗中的研究进展

Research progress of cell membrane biomimetic nanomaterial in tumor targeted therapy

细胞膜仿生纳米探针是一种新型探针,可通过EPR效应或分子靶标主动识别特定分子分型的肿瘤细胞,使肿瘤治疗从组织器官水平转向分子水平。同时,细胞膜纳米探针可减少机体内网状内皮系统的清除,体内循环时间亦明显延长。因此,其在肿瘤靶向精准治疗中显示出独特的优势。本文综述了几种典型的细胞膜仿生纳米探针在肿瘤靶向治疗方面的最新进展。

Cell membrane biomimetic nanomaterial is a new type of probe. Nanoparticles can bind to tumor cells through enhanced permeability and retention（EPR）effect by passive targeting and recognize specific molecular typing of tumor cells by active targeting,which turns tumor therapy from tissue and organ level to molecular level. At the same time,the cell membrane biomimetic nanoparticles can significantly prolong the targeting ability and circulation time of traditional nanoparticles,and thus enhance the therapeutic effect obviously. Therefore,it has shown unique advantages in the precise treatment of tumor targeting. In this paper,the latest development of several typical biomimetic nanoscale probes in tumor targeting therapy is reviewed.